Study On The Relationship Between Mayo Score And The Distribution Of Different TCM Syndromes Of Fecal Calprotectin And Ulcerative Colitis

Objective To explore the possible relationship between the Mayo score of ulcerative colitis disease activity and the monitoring of fecal calprotectin and TCM syndrome,and further explore the simple,rapid and sensitive relationship between UC TCM classification and conventional indicators.Syndrome differentiation provides convenient and objective indicators to better play the advantages of traditional Chinese medicine in the prevention and treatment of ulcerative colitis.Method 112 patients with Ulcerative Colitis(UC)were selected.According to the Consensus Opinions on Diagnosis and Treatment of Inflammatory Bowel Disease,the patients were identified as hot poisonous stagnation syndrome,large intestine dampness syndrome,spleen and kidney yang deficiency syndrome,cold and heat syndrome,Spleen deficiency syndrome,liver stagnation and spleen deficiency syndrome,6 syndrome groups.From the aspects of TCM syndrome differentiation,Mayo score and f'ecal calprotectin level,the data were analyzed and the SPSS22.0 software was used for data analysis.Result1.There were no significant differences in gender and age grouping between gender and age factors in the TCM syndrome group of UC patients.There was no significant difference in gender by X2 test(P>0.141),and there was no significant difference in age by t test.>0.656).2.There was a significant difference in the distribution of fecal calprotectin between the TCM syndrome groups in the total UC patients.The median type of damp-heat type was the highest,followed by cold-heat miscellaneous type,heat-toxic stagnation type,spleen-deficiency type,spleen-kidney yang deficiency type,liver.Yu spleen deficiency type.The difference was statistically significant(P<0.001).3.Comparing the distribution of Mayo scores of UC patients with the distribution of TCM syndromes,it was found that there was a statistical difference in the distribution of patients with various syndrome types during the active phase and the remission phase.During the active period,the large intestine was hot and humid,accounting for 41.6%,followe d by cold and heat miscellaneous type,liver stagnation and spleen deficiency type,spleen deficiency type,spleen and kidney yang deficiency type,and heat toxic blazing type.The remission period was dominated by liver stagnation and spleen deficiency,accounting for 45.5%,followed by spleen-deficiency type,spleen-kidney yang deficiency type,heat-toxin stagnation,large intestine damp-heat syndrome and cold-heat syndrome.In the Mayo severe activity score,the large intestine damp-heat syndrome was more common than the spleen-kidney yang deficiency group,the cold-heat-missing group and the spleen-deficiency group.The mild activity was more common in the liver-stagnation and spleen-deficiency group,which was significantly higher than the heat-toxic stagnation group and the large intestine.In the hot and humid group,the difference was statistically significant by X2 test(P<0.001).TCM syndromes suggesting ulcerative colitis are associated with disease activity.4.The relationship between TCM syndrome type and endoscopic score in patients with ulcerative colitis:the distribution of TCM syndrome type and endoscopic score of ulcerative colitis was statistically different(P<0.05).The maxillary damp-heat endoscopic score was 2.29±0.47,and the splee,n-deficiency endoscopic score was 1.13±1.22.5.Ulcerative colitis disease activity staging and endoscopic scoring:The Mayo score of UC patients was correlated with the endoscopic Baron score.After testing,P=0.009<0.05,Mayo activity of ulcerative colitis and endoscopic Baron score.There is a statistical difference between them.Baron scored 3 points for moderate activity and severe activity,and Baron scored 2 points for the most common moderate activity.6.There was a statistically significant difference between fecal calprotectin and different Mayo activity.The FC concentration of patients with active UC increased significantly,compared with the remission period,P<0.05,the difference was statistically significant.The FC concentration of different groups was different from the Mayo score.There was a statistical difference between the mild activity and the moderate and severe activity group(P<0.05),but there was no statistical relationship between the moderate activity group and the severe activity group.The difference P is greater than 0.05.Conclusions1.Fecal calprotectin concentration and disease activity index(Mayo score)are related to the TCM syndrome type of ulcerative colitis,which provides objective and convenient indicators for clinical differentiation of UC Chinese medicine,which is conducive to better guiding clinical diagnosis and treatment.It is worthy of clinical promotion and further research.2.There is a certain relationship between fecal calprotectin concentration and disease activity index(Mayo score),which can be used to distinguish between remission and active period of UC patients,but it is of little value to determine which period of activity the disease is in.Therefore,UC fecal calprotectin index and Mayo score can be used as one of the objective indicators of syndrome differentiation of ulcerative colitis in traditional Chinese medicine,which is worthy of further discussion.