Association Between Carotenoid Intake And Osteoporosis

Objective:With the advent of an aging society,the number of patients with many chronic diseases has risen sharply,including osteoporosis.At present,osteoporosis has become the main cause of bone pain and fracture in middle-aged and elderly people,which has brought heavy health and economic burden to people all over the world.Carotene is a common antioxidant nutrient in diet.To explore the relationship between carotene intake and osteoporosis,this study used data from the National Health and Nutrition Survey of the United States to analyze the relationship between carotene intake and osteoporosis,providing a new theoretical basis for the prevention of osteoporosis.Methods:Data are from the National Health and Nutrition Survey of the United States.Among them,24-hour dietary review data,questionnaires and physical examination data from 2005 to 2010 were used.In addition,food frequency data,questionnaire survey and physical examination data from 2005 to 2006 were used.IBM_SPSS24.0 software was used to process and analyze the data.The utilization rate and constituent ratio of counting data are described.Chi-square test was used to compare the counting data.Measurement data are expressed in the form of(χ±S)or M(Q),and t test,variance analysis or rank sum test are used.The correlation between measurement data is analyzed by Spearman correlation analysis.Multivariate linear regression model was used to analyze the association between bone mineral density of femur and spine versu the intake ofα-carotene andβ-carotene.Logistic regression model was used to analyze the relationship between osteoporosis versu the intake ofα-carotene andβ-carotene.Results:1.The osteoporosis prevalence of all subjects in this study was compared by gender,age,marital status,education and BMI,all difference were statistically significant(P<0.05).In the short-term 24 hour dietary review data of 2005-2010,the osteoporosis prevalence were significantly different in different energy intake andβ-carotene intake(P<0.05).In the long-term food consumption frequency data of2005-2006,there was no significant difference in the osteoporosis prevalence of different frequencies of oranges,peppers,broccoli,carrots,lettuce,tomatoes,broccoli and kidney beans(P>0.05).2.The BMD of femur and spine in all subjects with different gender,education and marital status had statistical significance(P<0.05).BMI was positively correlated with bone mineral density of femur and spine.In the 24 hour dietary review data of 2005-2010,energy intake and calcium intake was positively correlated with BMD of femur and spine,while age was negatively correlated with BMD of femur.There was no correlation between BMD and the intake ofα-carotene andβ-carotene.In the food consumption frequency data of 2005-2006,except broccoli consumption frequency,there was no significant difference in BMD of femur and spine among different food consumption frequencies(P<0.05).3.In the 24 hour dietary review data of 2005-2010,gender,BMI,age,race andβ-carotene were the influencing factors of femoral bone mineral density,and gender,BMI,educational level and race were the influencing factors of spinal bone mineral density.4.The 24 hour dietary review data of 2005-2010 results show,women aged60-69 years,70 years and above,divorce or separation,widowhood,energy intake>2400 kcal,α-carotene intake≥900 mcg/d,β-carotene intake 1000≤β<2000mcg/d were risk factors for osteoporosis.The protective factors of osteoporosis were18.5≤BMI<25,25≤BMI<30,BMI≥30 kg/m~2,α-carotene intake 300≤α<600 mcg/d,andβ-carotene intake≥3000 mcg/d.Conclusion:1.Female,age increased,education level 9-11 grade,marital status for divorce or separation,widowhood,unmarried,energy intake>2400 kcal/d for osteoporosis risk factors;education level high school or secondary school graduation,college graduation and above,BMI increased,energy intake 1800-2400 kcal/d for osteoporosis protection factors.2.Intake ofβ-carotene can improve the femur bone mineral density.3.α-carotene intake≥900 mcg/d,β-carotene intake 1000≤β<2000 mcg/d were risk factors for osteoporosis.α-carotene intake 300≤α<600 mcg/d andβ-carotene intake≥3000 mcg/d were protective factors for osteoporosis.Therefore,proper intake ofα-carotene andβ-carotene can enhance the skeletal health of the population and prevent osteoporosis.