Correlated Study Between Serum Immunoglobulins And Clinical Pathology Of Primary Kidney Disease

Purpose:Retrospective analysis age,sex,24 hours urinary protein,serum immunoglobulin,serum albumin,serum creatinine,pathological data of kidney biopsy of primary kidney disease patients,grasping the correlation between serum immunoglobulin and the clinicopathological indexes of primary kidney disease,helping clinical doctors to determine the patient's illness condition and the development trend,better treatment timing,take appropriate treatment in time,improving patient survival.Materials and Methods:Check medical records of patients can be clearly diagnosed as primary kidney disease ang did kidney biopsy in July 2016 to November 2018 in our hospital kidney department,and rule out medical records of diabetes,high blood pressure,systemic lupus erythematosus,anaphylactoid purpura and so on causing secondary kidney disease,the presence of diseases(e.g.infectious diseases)that may affect changes in serum immunoglobulin and serum albumin levels and the number of glomeruli on kidney biopsy was less than 5.a total of 107 cases in line with the research of medical records,using SPSS20.0 statistical software,analyzing age,sex,24 hours urinary protein,serum immunoglobulin,serum albuminin,serum creatinine,pathologicaldata correlation,comparing thechange ofthe relationshipbetweeneachother.Results:1.Among the 107 patients with pathological types,the most common one was membranous nephropathy,with 66 cases(61.7%),followed by IgA nephropathy,with28 cases(26.2%),minimal change disease in 7cases(6.5%),focal segmental glomerulosclerosis in 4 cases(3.7%),and membranous proliferative nephropathy in 2cases(1.9%).2.There was no significant statistical difference in serum IgG,IgM and IgA ofeach age group(P>0.05).3.Among the 107 clinical cases,the serum IgG and IgM levels in women with primary nephropathy were significantly higher than those in men,and difference was statistically significant(P<0.05),while there was no significant statistical difference in serum IgA levels between the two sexs(P>0.05).4.In 107 clinical cases,the statistics can be concluded that serum immunoplobulin IgG negatively correlated with the amount of 24 hours urinary ptotein,the difference was statistically significant(P < 0.05).IgA also negatively correlated,the difference was statistically significant(P<0.05).serum immunoglobulin IgM has nothing to do with the amounts of 24 hours urinary protein.the difference was no statistically significant(P>0.05).5.Serum IgG of immunoglobulin was positively correlated with serum albumin,the difference was statistically significant(P<0.05).Serum IgA in serum was positively correlated with the amount of albumin in serum,the difference was statistically significant(P < 0.05).Serum IgM was independent of serum albumin level,the difference was no statistically significant(P>0.05).6.The change of serum IgG,IgA,IgM were not statistically different from the change of creatinine(P>0.05).7.Serum IgG and IgA contents showed statistical difference in each pathological type(P < 0.05),while IgM showed no statistical difference in each pathological type(P>0.05).8.The positive rates of IgG and IgA in immunofluorescence were statistically different in each pathological type(P<0.05),while the positive rates of IgM were not statistically different in each pathological type(P>0.05).9.The change of serum IgG,IgA,IgM were not statistically different from immunofluorescence intensity in renal pathological biopsy(P>0.05).Conclusion:1.Compared with women,male patients are more likely to have large amount of proteinuria.2.Patients with significantly lower serum IgG and IgA level may have lowerserum albumin,suggesting that there may be a high coagulation state in the body,and patients' coagulation changes should be closely monitored.3.The contents of serum IgG and IgA were different in different pathological types of primary renal disease,and the positive rates of IgG and IgA in immunofluorescence were different in different pathological types.4.The change of serum immunoglobulin is not related to the deposition of renal pathological immune complex.