| Objective:To retrospectively analyze the changes of blood routine,myocardial enzymes and heart rate variability(HRV)related indexes in children with vasovagal syncope(VVS)and its clinical significance,further explore the risk factors ofVVS and provide clues for the diagnosis of VVS.Methods:Clinical information:The clinical data of 324 children with syncope who were treated in the Department of Pediatric Cardiology of the First Hospital of Jilin University from April 2015 to December 2018 were collected.The clinical manifestations were selected to meet the VVS and the HUTT results were positive.Children with echocardiography and other electrocardiograms were excluded from other causes of syncope.Children with gender and age-matched physical examination in the Children's Health Department of the First Hospital of Jilin University were selected as the control group for blood routine and myocardial enzyme indicators.Dynamic electrocardiogram was performed in the pediatric cardiology department of the First Hospital of Jilin University with gender and age matching,but children with congenital heart disease and arrhythmia were not identified as the heart rate variability control group.Research content:1.In the section of blood routine,67 patients in the VVS group,46 females,21 males,aged 6-16 years,mean age 11.42±2.60 years;91 children in the control group,49 females,42 males,age 8-16 years old,with an average age of10.67±2.39 years old.2.In the myocardial enzyme part,there were 35 children in the VVS group,27 females,8 males,aged 7-16 years,with an average age of 11.77±2.47years old;43 children in the control group,26 females,17 males,age 7-16 years old,with an average age of 10.65±2.52 years old.3.In the Heart rate variability part,30patients in the VVS group,aged 6-16 years,19 females,11 males,with an average age of 11.33±2.69 years;55 children in the control group,24 females,31 males,age5-15 years old,with an average age of 10.57±3.10 years old.Statistical methods:Measurement data were expressed as mean±standard deviation(c±S),t test was used for comparison between groups,mann-Whitney U was used for non-parametric test,and x~2 test was used for comparison between count data groups.The statistical software used was SPSS18.0.Results:1.In the blood routine part,the MPV of VVS group was higher than the control group,and the difference was statistically significant(P<0.05).2.Myocardial enzyme fraction,the CK of VVS group was lower than the control group,the difference was statistically significant(P<0.05).3.In the heart rate variability part,the SDNN was higher in the VVS group than in the control group(151.93±32.88 VS 134.14±34.36 ms).The minimum heart rate and average heart rate in the VVS group were lower than those in the control group.SDNN and SDANN were significantly higher in the VVS group who aged 12 or older than those under the age of 12(161.06±29.57 VS 133.00±30.16ms?146.18±23.65 VS121.42±35.48 ms).The above differences are statistically significant(P<0.05).There was no significant difference in heart rate variability between different genders in the VVS group and in children with?12 years in the VVS group and those in the control group.Conclusion:1.The MPV of children with VVS is higher than that of normal children.2.The CK value of children with VVS was significantly lower than that of the control group.3.The level of CK in children with VVS was related to gender,and the level of female CK was significantly lower than that of men.4.In the comparison of heart rate variability analysis,the SDNN of the children in the VVS group was higher than that of the control group;the minimum heart rate and the average heart rate were lower than those of the control group.5.Children with VVS who age 12 or older had higher SDNN and SDANN than children with VVS less than 12 years of age. |
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