| Objected Amyotrophic lateral sclerosis(ALS)is a fatal disease that causes motor neuron degeneration and progressive paralysis.The symptoms and signs of motor neuron injury in upper and lower motor neurons are the clinical features of ALS.The specific expression is muscle weakness,muscle atrophy and pyramidal tract sign and so on different combination,feeling and sphincter function is generally not affected.ALS is a rare disease,with an incidence of(1-2)/ 100,000 in the population,and the prevalence is about(4-6)/100,000.The disease is not only fatal,but the disease has a duration of two to five years,which can cause great harm to the patient both physically and mentally.Due to the increasing incidence of the disease in recent years,the effect of this disease on society is gradually increasing.At present,foreign scholars have made some explorations on the risk factors of ALS,but many of the dangerous factors reported have many contradictions.Moreover,China and other countries have different geographical,cultural,economic and ethnic differences,and some risk factors found abroad may differ from those in China.In China,there is still a lack of research on the risk factors for ALS.This study through the investigation of ALS patients generally,infection situation andhistory of disease,living habits,eating habits,living environment,and occupational exposure factors in several aspects,such as,explore the risk factors of the onset of ALS,which will provide a scientific basis for ALS to prevent in the future.Methods(1)Collected from the first affiliated hospital of guangxi medical university from January 2011 to November 2016 in the hospital diagnosed with muscular atrophy of amyotrophic lateral sclerosis(ALS)patients as cases(after electrophysiology and neural imaging examination confirmed).A total of 35 patients were collected,and 15 cases were finally effective.Then,a total of 60 cases were found in the patient's residence by 1:4.Finally,the researchers adopted a uniform questionnaire to collect data.(2)All data entry,establishing a database,using SPSS22.0 analysis software for data processing.First we use conditional Logistic regression for each project to make the single factor analysis,and statistical significance was found in the single factor analysis of factors covered by conditions multiariable Logistic regression analysis,to evaluate the comprehensive function of various factors,with P < 0.05 says the difference is statistically significant.Result(1)In general,the gender and age balance of ALS patients and control groups were comparable.There were 15 patients with ALS,the oldest was 65,the youngest was 41,and the average age was 57.The control group was 60,the oldest was 70,the youngest was 39,and the average age was 56.The age difference between the two groups was not statistically significant(?2=0.38,P=0.54).There was no significant difference between the two groups.(2)None of the 15 cases had a family history of ALS.None of the 60 controls had found a family history of ALS.(3)Single factor analysis,according to the results of ALS patients and control group in often drink milk,often eat salted food(includingsauerkraut,pickles,pickled food acid wild,etc.),often eat animal internal organs and head and neck injury history comparative difference was statistically significant.The risk of head and neck trauma increased most,OR 25.64(95%Cl3.13~209.78,P=0.002).Often eat cured food OR 9.22(95% Cl 1.84~46.20,P=0.01).Often drink milk OR 6.19(95% Cl1.11~34.39,P=0.04).Often eat animal viscera OR 4.78(95% Cl 1.12~20.45,P=0.04).However,multivariate analysis showed that only the history of head and neck trauma was the risk factor for ALS(OR 12.50,P=0.03).Conclusion The history of head and neck trauma is the risk factor of ALS... |
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