| ObjectiveThrough clinical observation of the effect of Shenqi Fuzheng injection on leukopenia after chemotherapy in diffuse large B-cell lymphoma,this study provides a basis for TCM treatment of leukopenia after chemotherapy in lymphoma.MethodsFifty-eight patients with diffuse large B-cell lymphoma diagnosed by pathology from November 2017 to December 2018 in the Department of Hematology,Tongde Hospital of Zhejiang Province were collected.58 patients were randomly divided into treatment group and control group.The treatment group and the control group were treated with(R)CHOP-like or(R)EPOCH-like regimens.Blood routine was monitored after chemotherapy in both groups.If the white blood cell count was less than 2.0x10~9/L,300ugQD was injected subcutaneously.If the white blood cell count was less than 1.0x109/L,150ugQD was injected subcutaneously,until the white blood cells recovered to 2.0x10~9/L.The treatment group began to use Shenqi Fuzheng Injection 250ml intravenous drip on the first day of chemotherapy,once a day,for 10 days.Data were collected during the course of chemotherapy.Leukocyte recovery days,recombinant human granulocyte colony stimulating factor usage,leukocyte and neutrophil counts at different time of chemotherapy were compared between the two groups,and the efficacy was evaluated according to the evaluation criteria after the end of chemotherapy.All data were analyzed by SPSS20.0 statistical software,p<0.05,the difference was statistically significant.Results1.Leukocyte and neutrophil count at different time after chemotherapy:The mean value of leucocyte and neutrophil in treatment group was higher than that in control group at different time after chemotherapy.There were significant differences between the two groups in leukocyte count at 7 days after chemotherapy,neutrophil count at 7 days after chemotherapy,leukocyte count at 10 days after chemotherapy,neutrophil count at 10 days after chemotherapy and neutrophil count at 14 days after chemotherapy(p<0.05).There was no significant difference in white blood cell count between the two groups after 14 days of chemotherapy(p>0.05).The variance analysis of repeated measurements showed that there were significant differences between white blood cells and neutrophils(p<0.05).2.Leukocyte recovery days:The control group had 6.32(+1.335)days of leucocyte recovery and the treatment group had 5.43(+1.794)days of leucocyte recovery.There was a significant difference between the two groups(p<0.05).3.Use of recombinant human granulocyte colony-stimulating factor:The average use of Ruibai in the control group was 2289.29(+453.251 ug),higher than that in the treatment group in 2006.67(+701.075 ug),but there was no significant difference(p>0.05).4.Incidence of infection:36.7%in the treatment group and 46.7%in the control group,there was no significant difference(p>0.05).5.Evaluation of Western Medical Effectiveness:The total effective rate of the treatment group was 96.7%,and that of the control group was 89.3%.There was no significant difference between the two groups(p>0.05).6.Evaluation of curative effect of TCM:The total effective rate of the treatment group was83.3%,and that of the control group was 64.3%.There was a significant difference between the two groups(p<0.05).ConclusionShenqi Fuzheng Injection can significantly reduce the rate of leukocyte decline in patients with diffuse large B-cell lymphoma after chemotherapy,reduce the degree of leukocyte decline,increase the rate of leukocyte recovery,reduce the days of leukocyte recovery,significantly improve the clinical symptoms of qi deficiency syndrome such as shortness of breath,fatigue,and improve the quality of life of patients. |
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