Investigating The Changes Of ALFF And ReHo Of Related Cortex Of Infants With Sensorineural Hearing Loss By Using FMRI

Objective: To study the changes of ALFF and Re Ho in hearing,language,vision and other related brain regions of children with bilateral congenital severe sensorineural deafness aged 0-4 years by resting-state functional magnetic resonance imaging,and to evaluate the functional reorganization of hearing,language,vision and other related brain regions before cochlear implantation.Methods: Twenty-five children aged 0-4 with bilateral congenital severe sensorineural deafness and 20 normal hearing children were divided into four groups: 16 children aged 0-2years old with deafness,9 children aged 0-2 years old with control group,9 children aged2-4 years old with deafness and 11 children aged 2-4 years old with control group.Resting-state functional magnetic resonance(fmr)scans were performed with GE 3.0T magnetic resonance imager in deaf and normal groups,and resting-state f MR data were analyzed with low-frequency amplitude(ALFF)and local consistency(Re Ho).Results: Compared with ALFF of normal subjects aged 0 to 2 years,ALFF increased in the left anterior cuneiform lobe,right superior frontal gyrus,right middle occipital gyrus and right parietal lobule,and decreased in the left superior temporal gyrus and left inferior frontal gyrus.The left anterior cingulate gyrus and left infratemporal gyrus were higher in2-4 year-old deaf subjects than in 2-4 year-old normal subjects.The brain regions with decreased ALFF values were left inferior frontal gyrus and left superior temporal gyrus.Compared with 0-2 years old deaf patients,ALFF increased in left superior temporal gyrus,left inferior frontal gyrus and insula,and decreased in right medial frontal gyrus and left inferior temporal gyrus.Compared with the normal subjects aged 0 to 2 years,the brainregions with increased Re Ho were left spindle gyrus,and the brain regions with decreased Re Ho were left superior temporal gyrus and left inferior frontal gyrus.Compared with the normal subjects aged 2 to 4 years old,the brain areas with increased Re Ho were left anterior cuneiform lobe,right parietal lobule,left suboccipital gyrus and right cuneiform lobe.Re Ho decreased in the left superior temporal gyrus and right angular gyrus.The right superior temporal gyrus was higher in deaf patients aged 2 to 4 years than in deaf patients aged 0 to 2years,and the left medial frontal gyrus was lower in deaf patients aged 2 to 4 years.Conclusion: Low-frequency amplitude and local consistency can better reveal the changes of BOLD signal caused by abnormal brain activity in children with bilateral congenital severe sensorineural deafness.Functional remodeling may occur in the auditory,linguistic,visual and other sensory cortex of children with congenital bilateral sensorineural deafness,suggesting that cochlear implantation may occur after 2 years of age due to hearing,visual and other sensory systems.The functional reorganization of language and other brain areas affects the effect of hearing rehabilitation.Functional magnetic resonance imaging(fmri)is helpful to preoperative evaluation and prognosis judgement of cochlear implants.