Relationship Between Haemoglobin Glycation Index And Risk Of Diabetic Peripheral Neuropathy In Patients With Type 2 Diabetes

Objective:To explore the relationship between haemoglobin glycation index(HGI)and risk of diabetic peripheral neuropathy(DPN)in patients with type 2 diabetes(T2DM).This study provided a theoretical basis for using HGI to assessment the risk of DPN in T2DM.Methods:(1)The total of 726 cases of hospitalized patients with T2DM from January 2016 to December 2017 were enrolled into the study.All enrolled patients were diagnosed as diabetes according to the 1999 WHO Diabetes Diagnostic Criteria.DPN diagnostic criteria was referred to the relevant standards of the 2017 China Type 2 Diabetes Prevention Guidelines.Exclusion criteria encompassed:Type 1 diabetes patients;patients who had acute complications of diabetes such as diabetic hyperosmolar coma,diabetic ketoacidosis,etc;patients with various types of acute or chronic infection;patients with neurological diseases such as cerebral infarction,cerebral hemorrhage,alcoholism,disc herniation,vitamin B12 deficiency,etc.(2)The clinical data of 726 patients were collected to evaluate the correlation between fasting plasma glucose(FPG)and glycosylated hemoglobin(hemoglobin A1c,HbA1c).A linear regression equation was drived from 285 randomly extracted patients.(3)FPG values from the remaining 441 patients were used to calculate predicted HbA1c.HGI was calculated as the difference between the observed HbAlc value and the predicted HbAlc.According to the HGI value,all the subjects were divided into low HGI group,middle HGI group and high HGI group.SPSS 23.0 software was used to analyze the data.The clinical data were compared among the three groups and the correlation between HGI levels and the prevalence of DPN was analyzed.P<0.05 was considered to be statistically significant.Results:(1)There were no significant differences in gender,course of disease,2h-PG,triglyceride,low-density lipoprotein cholesterol,high-density lipoprotein cholesterol,white blood cell count,hematocrit,hemoglobin,serum creatinine,glomerular filtration rate,blood urea nitrogen and urine microalbumin(P>0.05).There were significant differences in age,BMI,SBP,DBP,MBP,Fasting C-peptide,FPG,HbAlc,TC,and SUA among the three groups(P<0.05).(2)The prevalence of DPN in the three HGI groups were 73.5%,79.6%,and 85.0%,respectively.The prevalence risks of DPN were 1.773 in high HGI group when compared with low HGI group(P<0.05).(3)Logistic regression analysis showed that age[OR95%CI 1.011(1.003,1.019),P<0.05],diabetes duration[OR95%CI 1.091(1.040,1.145),P<0.05]and HGI[OR95%CI 1.259(1.006,1.574),P<0.05]were risk factors for DPN.Conclusion:The relationship between HGI and risk of DPN in patients with type 2 diabetes were positively correlated.HGI may be used as one of the risk predictor of DPN in patients with T2DM.