Prognostic Value Of Electrocardiographic Non-specific ST-T Segment Abnormalities For Cardiovascular Events In Patients On Peritoneal Dialysis

Objectives:Electrocardiographic non-specific ST-segment and T-wave(ST-T)abnormalities are common in peoples.Recently,Many studies have indicated that these abnormalities were known predictors of cardiovascular(CV)mortality in the general population,and were significantly associated with cardiovascular(CV)morbidity and mortality.yet their prevalence in patients on peritoneal dialysis(PD)has not been evaluated.Therefore,this study To evaluate the prognostic value of electrocardiographic non-specific ST-T abnormalities for cardiovascular(CV)events in patients on peritoneal dialysis.Methods:This is a single-center and retrospective cohort study,All patients who started PD from November 1,2005,to February 28,2017,in the First Affiliated Hospital of Nanchang University.An electrocardiogram(ECG)was defined by Minnesota coding,According to the results of the ECG,patients were divided into 2 groups: ST-T abnormal group and ST-T normal group.The Primary outcome is cardiovascular(CV)events,the secondary outcome is cardiovascular(CV)mortality.Outcomes were analyzed by the Kaplan-Meier method.Multivariate Cox proportional hazards models were utilized to assess the risk factors of cardiovascular(CV)events.Results:1.648 eligible PD patients were enrolled,mean age was 48.25±14.08 years,Chronic glomerulonephritis(69.3%)was the most primary disease,331(51.08%)patients were male,the median follow-up was 48.25±14.08 months,90(13.9%)patients have cardiovascular(CV)events,135(20.8%)patients were death,69(51.1%)patients were CV death,260(40.1%)patients were ST-T abnormal,388(50.9%)patients were ST-T normal;2.The KM survival curves and Multivariable Cox regression analysis(Afteradjustment for sex,age,systolic blood pressure,diabetes,Neutrophil percentage,Serum creatinine,Triglyceride,Total cholesterol,Lipoprotein a(Lp a),Blood potassium,Blood calcium)found:1)Compared with ST-T normal group,patients with ST-T anormal have significantly higher risk of cardiovascular events(HR=1.687,95%CI=1.015-2.804,P=0.044);2)Female patients with ST-T anormal have significantly higher risk of cardiovascular death,Compared with ST-T normal group(HR=4.556,95%CI= 1.583-13.115,P=0.005).Conclusions:1.Electrocardiographic non-specific ST-T abnormalities were common in patients on peritoneal dialysis.2.non-specific ST-T abnormalities were the indepenpent risk factor of cardiovascular events in patients with peritoneal dialysis.3.non-specific ST-T abnormalities were the indepenpent risk factor of cardiovascular events in female patients with peritoneal dialysis.