| Purpose(1)To analyze the etiological and epidemiological characteristics of influenza(flu)among influenza-like population in Guangzhou region and provide evidence for influenza prevention and control.(2)To evaluate the clinical characteristics and treatment efficacy of childhood influenza(flu)in Guangzhou from 2017 to 2018.Methods(1)Medical record of the patients diagnosed with influenza from August 2017 to May 2018 in Nanfang Hospital,Southern Medical University were retrospectively evaluated.We then compared the difference in flu subtypes,epidemical time distribution,gender and age characteristics of susceptible populations by Chi-square test in SPSS 20.0 software.(2)We firstly analyzed the clinical characteristics and laboratory testing resultsof the Flu cases.Then,we divided the 131 childhood flu cases into two groups according to their treatment strategies:the oseltamivir group(93 cases)and the control group(38 cases).The symptoms duration(fever,myalgia,cough and sore throat)and the total effective rate were compared between these two groups.Results(1)A total of 7075 patients with influenza-like symptoms and signs were admitted to the hospital during the period.Among them,1307(18.5%)patients were finally diagnosed as influenza,including 486 cases of influenza A and 821 cases of influenza B.The high incidence of flu was found during Dec.2017 to Mar.2018(χ2=:311.226,P<0.001),while other months were sporadic epidemics.Besides,1230 flu cases were confirmedduring Dec 2017 to Mar 2018,including 424 cases of influenza A(34.47%)and 806 cases of influenza B(65.53%).Furthermore,juvenile population aged 1 to 17 was found a relative high positive rate of flu(26.87%),among whom,the highest rate(31.31%)was found in primary school children aged 6 to 11.In contrast,people aged over 65 has the lowest incidence rate(6.25%)(χ2=172.351,P<0.001).(2)The high incidence of flu was found between Dec.2017 and Feb.2018,the epidemic strain was presented to be a mixed infection of flu type A and B,while the dominant strain was the flu B virus.There is no significant difference in clinical symptoms and laboratory test between the flu group and non-flu group,except for exhaustion(P=0.02),abnormal lung auscultation(P=0.004),and decreased lymphocyte ratio(P<0.001);Besides,there is no significant difference in clinical symptoms and laboratory test between flu A group and flu B group,except for soreness(P=0.006)and expectoration(P=0.041).In addition,the duration of fever,cough and sore throat in the oseltamivir group were all significantly shorter than that of the control group(P<0.01).Conclusion(1)The high incidence of this flu epidemic in winter of Guangzhou was found in Children.The epidemic trend of influenza should been monitored in orgder to discover the mutants in time and facilitate effective prevention and control.During this influenza epidemic,which was characterized by mixed infection of flu type A and B mixed infection,flu B virus was dominant.(2)The high incidence of this flu epidemic in Guangzhou was found in winter,and the epidemic strain was presented to be a mixed infection of flu type A and B,while the dominant strain was the flu B virus,which was partially "missing" of the trivalent influenza vaccine as the privilege.Our study supported that diagnosis of influenza should mainly rely on pathogen examination.(3)Oseltamivir,as the treatment option in childhood flu,can not only shorten the course of disease but also improve the total effective rate of treatment,which was worthy of popularization and application. |
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