Preparation,Characterization And Properties Of WO_x@PEG-Gd Nanocomposite

Photothermal therapy is an effective and non-invasive method for the treatment of cancer.PTT can not only ablate tumor cells by generating heat,but also promote photodynamic therapy,chemotherapy and other treatments.It becomes urgent to find an efficient and inoffensive photothermal conversion agent.The complexity,diversity,and rejection of cancer limited the application of photothermal therapy.Therefore,the discovery of a precise,efficient,non-toxic and harmless photothermal conversion agents will be urgent in cancer treatment.W₁₈O₄₉ nanoparticles have been used as photothermal conversion agents widely.W₁₈O₄₉@PEG nanowires,W₁₈O₄₉-Gd nanosphere network and W₁₈O₄₉@PEG-Gd nanowires were constructed and characterized by W₁₈O₄₉doping with Gd and modification with PEG.W₁₈O₄₉ nanoparticles were prepared by solvothermal method using n-propanol and ethanol as solvents respectively.The UV-visible-near-infrared absorption properties of the samples showed great biocompatibility,and MCF-7tumor cells were killed.After 24 hours,under 808 nm near-infrared light,the survival rate was only 40%or less.W₁₈O₄₉@PEG nanostructures were constructed by stirring synthesis,ultrasonic synthesis and solvothermal method,respectively.Microstructural analysis and related photothermal performance tests were performed.Under the same conditions,the temperature of W₁₈O₄₉@PEG ratio.After 10 minutes of 808 nm near-infrared light irradiation was increased.The W₁₈O₄₉-Gd nanostructure was synthesized by solvothermal method using lanthanum nitrate hexahydrate as the source.The molar ratio n_w:n _Gd of different tungsten ruthenium was adjusted,and the nano Line-Sphere-Line structure was obtained by TEM.The photothermal properties of W₁₈O₄₉-Gd nanostructures under different ratios were studied,the thermal diffusivity was simulated,and the magnetic properties and magnetic resonance imaging were tested.The WO_x@PEG-Gd nanocomposite constructed by one-step solvothermal method to investigate the effects of different Gd doping ratios and different reaction temperatures.The XRD test showed that the sample was tested for the microstructure,surface group,photothermal property and magnetic properties of the sample.The results showed that the composite had the potential of photothermal therapy for tumor under multi-mode imaging.