Studies On Chemical Components And Bioactivities Of One Species Of Soft Corals And One Species Of Marine Sponges Collected From South China Sea

Marine organisms have become an important research content of marine natural products due to their various types and complex ecological environment.Marine organisms can produce secondary metabolites with novel structures and significant activities,which play a vital role in the development of new drugs.In the search for novel and biologically active secondary metabolites,we systematically studied two marine organisms(including one Lobophytum sp.soft coral and one Hyrtios erectus sponge)collected off the coast of South China Sea.Compounds were separated and purified by silica gel and high-performance liquid chromatograph.Moreover,their structures were elucidated on the basis of spectroscopic analysis and by comparison with those reported in the literature.From the acetone extracts of soft coral Lobophytum sp.and sponge Hyrtios erectus,we obtain 80 compounds,including diterpenoids,steroids,alkaloids,and sesterterpenes.Out of them,20 of them were identified as new compounds,named as Lobophytrol A-N,Lobophysterol A-D,Hyrtiosin F,and Hyrtiosin G.In bioassay,Lobophysterol D showed weak cytotoxicities against HT-29,SNU-398,and Capan-1 cells.