| At present,Chinese herbal medicine has received extensive attention worldwide.The therapeutic mechanism of Chinese herbal medicine is compared with the therapeutic mechanism of western medicine at the molecular level.The treatment mechanism of most Chinese herbal medicines is still unclear.How to integrate Chinese herbal medicine with modem medicine,computer-aided modernization research of Chinese herbal medicine is particularly important.Virtual screening,pharmacophore model,machine learning and other methods for predicting the medicinal properties of Chinese herbal medicines are extremely important methods for computer-assisted modernization of Chinese herbal medicine.More and more Chinese herbal compounds are widely used as candidate drug compounds.An important way for pharmaceutical companies to develop drugs is to find potentially active compounds with relevant targets from Chinese herbal medicines.Among the many methods for predicting the medicinal properties of Chinese herbal medicines,virtual screening technology has strong reliability,fast prediction speed and good prediction accuracy,so it has always been at the core of the Chinese herbal medicine compound drug prediction method.Special medical use formulas are directly or gastrointestinally administered to provide nutritional support to nutritionally deficient clinical patients.It is a brand new product for clinical patient nutrition support.Special medical use formulas are gradually admired by clinicians and dietitians because of their advantages of preventing gastrointestinal function deterioration,easy storage and transportation,and low price.However,the ingredients for special medical use formulas on the market are relatively simple,and the source of nutrients is single.Firstly,the paper comprehensively studied the above bioinformatics-based drug-based prediction methods.The bioinformatics-based drug-based prediction method has good results in the drug-like analysis of the whole database and the drug-like prediction of specific candidate compounds,effect.In the drug-like analysis of the overall database,a comprehensive systematic analysis based on eight molecular descriptors was performed on the compounds in the chemical catalog database,the drug database and the Chinese medicine compound database.In the prediction of the drug-like properties of specific candidate compounds,the drug-like properties of jujube polysaccharides were predicted,and the application of jujube polysaccharides in formulas for special medical uses was proposed.The paper further developed a speeial medical formula formula fbll-nutrition formula with Chinese jujube as the main raw material,and screened and optimized the formula from the perspective of nutrient balance.Finally,since the raw materials of the developed products are all powder and granules,the finished product is obtained by a dry process.The problem of the balance between the mixing uniformity of the granular material and the mixing time and cost has always been a difficult problem to be solved by the dry process.Therefore,based on the full study of the raw material mass fraction,particle size distribution,Carr fluidity index,bulk density,water content,establish a suitable mixing process to test.Through the analysis of mixing time,mixed loading,and mixing speed,find the balance between time,cost and mixing uniformity.In summary,the paper studies the chemical catalog database,drug database and Chinese herbal compound database based on molecular descriptors,and concludes that the molecules in the Chinese herbal compound database have more drug-like characteristics than other source compounds.The drug-like properties of jujube polysaccharides were analyzed to determine their strong drug-like properties and biological activities.The formulation of special medical formulas was screened and optimized from the perspective of nutrient balance.The balance of time,cost and mixing uniformity is found by analyzing the mixing time,the mixing amount and the mixing speed. |
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