Study On Relationship Of Lymphovascular Invation With Clinicopathological Features And Prognosis In Breast Cancer Patients

Objective:Study on the relationship between lymphovascular invasion and clinicopathological features and prognosis retrospectively in 239 patients with breast cancer.Method:Collected from January 2010-2011 in December by the Zhengzhou University People’s Hospital(Henan Provincial People’s Hospital)breast surgery admitted 239 cases of invasive breast cancer patients for the study,summarized the clinical and pathological data,retrospective analysis Luminal A,Luminal B,Her-2 overexpression and Basal-like breast cancer in patients with vascular thrombosis and its relationship with clinicopathological features and 5a survival.By SPSS22.0 software for data calculation and analysis,Comparisons between groups were performed using χ2 test(Fisher exact test was used if necessary).The statistical results were statistically significant at a p <0.05.Survival curves were drawn by Kaplan-Meier method and Log-rank test was used to compare the survival rates.Univariate and multivariate analyzes were performed using the 95% confidence interval of COX proportional hazards model.Results:(1)There was no significant difference in the occurrence of lymphovascular invasion between different molecular classification of breast cancer(p>0.05).Luminal B type has a higher incidence of lymphovascular invasion(34.1%),Basal-like type showed a lower incidence of lymphovascular invasion(16.3%);(2)Univariate analysis showed that lymphovascular invasion and molecular classification were related to the prognosis of patients with DFS.The prognosis of patients with lymphovascular invasion positive prognosis worse than negative.The prognosis of patients with Basal-like type was higher than those with Luminal A type and Luminal B type DFS poor prognosis,Her-2 type patients with prognosis worse than Luminal B type;(3)Univariate analysis showed that the prognosis of patients with lymphovascular invasion was worse than that of negative ones in patients with lymphovascular invasion,molecular classification and menopausal status.The prognosis of patients with Basal-like was higher than that of those with Luminal A type,The prognosis of patients with poor prognosis of Luminal B type is poor,and the prognosis of OS in postmenopausal patients is worse than that of those without menopause.However,age,stage and other factors have no effect on the prognosis of patients;(4)Multivariate COX survival analysis showed that lymphovascular invasion and molecular classification were independent prognostic factors in patients with DFS and were risk factors for prognosis of poor prognosis of DFS in patients with positive lymphovascular invasion and poor outcome in patients with molecular classification of Basal-like type Patients with Luminal A type have poor prognosis;(5)Multivariate COX survival analysis showed that lymphovascular invasion and molecular classification were independent prognostic factors in patients with OS,and as a risk factor,lymphovascular invasion positive patients than negative patients with poor OS prognosis.The molecular classification was Her-2 type had a worse prognosis than Luminal A type.The prognosis of patients with luminal A type was worse than that of Luminal A type.The prognosis of patients with luminal A type was not correlated with OS prognosis.Conclusion:(1)Lymphovascular invasion and molecular classification and the prognosis of patients with DFS,lymphovascular invasion positive prognosis than negative prognosis.(2)Lymphovascular invasion,molecular classification,menopausal status and patient OS prognosis,prognosis of patients with lymphovascular invasion than negative prognosis.(3)Lymphovascular invasion and molecular classification were independent factors affecting the prognosis of patients with DFS,OS,and as a risk factor.