| ObjectiveIn this study,Yuganzi oral spray was used to treat xerostomia of patients with general anesthesia laparoscopic surgery,compared with warm water oral spray,to verify whether Fructus Glycyrrhizae(Yu Gan Zi)has the effect of promoting saliva secretion of glands or not.At the same time,the efficacy and safety of Yuganzi oral spray in relieving xerostomia were observed,which can provide evidence for the application of it in clinical practice.MethodsIn this study,sixty-four patients with endotracheal intubation who received gynecological laparoscopic surgery during a period from February 2017 to September 2017 in gynecology department of a Third Grade Class A Hospital in Guangzhou,were randomly assigned to the exercise group and control group,32 patients in each group.Each patient in the exercise group underwent oral intervention by using Yuganzi oral spray,while warm water oral spray is used in the control group.The intervention measures are as fO]lows:one spray was respectively applied to the mucous membranes of cheeks,lingual surface and hypoglossis.The patients' salivary flow rate and oral mucosal moisture degree were measured after surgery.During 6 hours of fasting and water deprivation,the experimenter gave the patient oral spray every 15 minutes and their salivary flow rate and oral mucosal moi sture degree were measured 7 times per hour.Then the clinical effect of Yuganzi oral spray on postoperative xerostomia was evaluated.ResultsIn the experiment,there wore 6 cases dropping out,3 cases in each group,and 58 cases were completed.In the exercise group,one patient had to be transferred to hepatological surgery department for postoperative treatment,and the other two patients both suffered from nausea and vomiting caused by anesthesia after surgery,so the 3 cases was dropped out.While in the control group,one patient suffered from acute pulmonary edema before postoperative intervention;one patient was unwilling to accept data collection,and the other one patient had frequent postoperative nausea and vomiting associated with hiccups that can't continue to test,so they were also withdrawal.There were 58 effective cases,29 cases in each group.There was no significant difference in anthropological differences between the patients of the two groups,such as age,height and weight(P>0.05),the same as the experimental baseline data including anesthesia duration,preoperative basal salivary flow rate,and oral mucosal moisture(P>0.05),which indicate that the two groups were comparable.During the six hour of intervention,the salivary flow rate of the two groups generally increased as time went on,but until the sixth hour of intervention,the salivary flow rate of the patients did not return to their preoperative level.However,according to the ANOVA analysis of repeated measurement data,it was found that the saliva flow rate of the patients treated with Yuganzi oral spray is significantly higher than that of the patients with warm water oral spray.The lip and tongue oral mucosal moisturizing degree of the two groups increased gradually with time,but the degree of lip and tongue mucosal moistening of the experimental group with Yuganzi oral spray was significantly higher than that of the control group treated with warm water spray.After 6 hours of intervention with Yuganzi oral spray,the patients' lip and tongue oral mucosal moisturizing degree could be restored to the preoperative baseline level.By contrast,after 6 hours of intervention with warm water oral spray,the patients' lip and tongue oral mucosal moistening degree was increased significantly compared with the postoperative level,but failed to recover to the preoperative baseline level.Conclusions1.In the concentration screening experiment for blending the Yuganzi oral spray,the proportion of Yuganzi(dried Fructus Phyllanthi)and water was 1:20,1:10 and 1:5.The results showed that the oral spray of Yuganzi(dried Fructus Phyllanthi)and water at 1:5 proportion had the best effect on increasing the salivary flow rate of the normal people,which was worth applying and popularizing.2.In this study,dried Fructus Phyllanthi(Yu Gan Zi)was applied to treat xerostomia after gynecological laparoscopic surgery under the guidance of relevant basic theories.Compared with the conventional warm water oral spray,the salivary flow rate and oral mucosal moisture degree during the period of fasting and water deprivation were significantly increased by using Yuganzi oral spray,so the duration of postoperative xerostomia was shortened,and the perioperative comfort of the patients was increased,which can provide the basis data for clinical treatment for postoperative xerostomia. |
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