| Background:Around the world,lung cancer is the most usual type of cancer and is also the leading cause of cancer death.In China,lung cancer has the highest incidence of malignant tumors,and it has also become the first cause of death among cancer people.Non-small cell lung cancer(NSCLC)accounts for about 85%of the total number of lung cancer.Up to now,surgery is still most effective method to cure lung cancer,but because of the atypical early symptoms and the uneven development of medical conditions in various regions of our country,most patients are in the middle and late stage at the time of treatment.The 5-year survival rate was only 16.1%.Lipid is an important energy storage substance in the body,and lipid is also an important structural component of cell membrane,which is important to maintain the stability of cell membrane,transmit signals and regulating cell metabolism.Many studies have confiramed that in the process of tumor occurrence and development,the level of blood lipid metabolism of the body will also produce corresponding changes.At present,there is no consistent result on the changes of blood lipid levels in patients with lung cancer.The purpose of this study was to detect serum triglyceride(TG),total cholesterol(TC),low density lipoprotein(LDL)and high density lipoprotein(HDL)in patients with non-small cell lung cancer(NSCLC).It also analyzes the relationship between it and the clinical characteristics of non-small cell lung cancer,and provides predictive help for tumor treatment.Objective:Detecting the levels of serum TG,TC,LDL and HDL in patients with NSCLC to reflect the characteristics of blood lipid metabolism,and the relationship between lipid level and clinical characteristics of NSCLC.At the same time,the changes of serum lipid before and after chemotherapy were used to predict the curative effect of chemotherapy.Methods:The basic information,hematological examination,pathological examination and imaging examination of target lesion of 188 patients with non-small cell lung cancer diagnosed for the first time in Jinan Central Hospital from July 1,2013 to July 1,2017 were collected retrospectively.Such as sex,age,smoking status,histological type and stage,as well as the next treatment in our hospital and the related examination data of patients with advanced unresectable non-small cell lung cancer after using two cycles of first-line chemotherapy regimen.At the same time,100 healthy persons in the physical examination center of our hospital were selected as the healthy control group,and the age and sex were matched with the lung cancer group.The data were analyzed by SPSS 22.0 software package,the data were expressed by x ąs,the mean comparison between the two groups was analyzed by independent t test,if the data did not satisfy the normal distribution,the Wilcoxon rank sum test was used,and the single factor analysis of variance(ANOVA)was used to analyze the data among multiple groups,and the data were analyzed by single factor analysis of variance(ANOVA).Paired t-test was used to evaluate the changes of blood lipid level in different curative effect groups after chemotherapy,P<0.05 was considered to be statistically significant.RECIST method was used to evaluate the efficacy of chemotherapy.All patients were reclassified by IASLC International Lung Cancer staging(eighth edition)in 2016.Results:1.The levels of TC and HDL in patients with non-small cell lung cancer were lower than those in healthy people,and the difference was statistically significant(p<0.05);Although the level of TG in patients was lower than that in normal people,but there was no significant difference between the two groups(p>0.05).The level of LDL was higher than that of healthy group,and the difference was not statistically significant(p>0.05).2.The levels of TC and HDL in female non-small cell lung cancer patients were higher than those in male patients(p = 0.013,p = 0.002),and the difference in blood lipid level was not related to the age difference of the patients(p>0.05);the HDL level of non-small cell lung cancer patients with no smoking history in the past was higher than that of patients with smoking history(p=0.002).The levels of TG,TC and HDL in adenocarcinoma group were higher than those in squamous cell carcinoma group,and the difference was statistically significant(p=0.016,p=0.014,p=0.029),but there was no significant difference in blood lipid level with or without lymph node or distant metastasis(p>0.05).The levels of TC,TG,HDL and LDL in patients with non-small cell lung were not related to the clinical stage of the patients(p>0.05).3.After 2 cycles of first-line chemotherapy,the levels of TG,TC,HDL and LDL in PR group were higher than those before chemotherapy(p<0.05).The levels of TC,HDL and LDL in patients with SD after chemotherapy were significantly higher than those before chemotherapy(p<0.05),and the levels of TG were not significantly different from those before chemotherapy(p>0.05).The levels of HDL in patients with PD after chemotherapy are a little bit lower than before treatment,but the levels of other indexes were higher than those before treatment,but there was no significant difference(p>0.05).4.In patients with squamous cell carcinoma,the levels of TG,TC,and LDL after chemotherapy increased compared with those before chemotherapy,and the difference was statistically significant(p<0.05).The efficacy of patients with SD and PD,the levels of TG,TC,HDL and LDL were not significantly different from those before chemotherapy(p>0.05).There was no significant difference in the levels of TG,TC,HDL and LDL between the patients with PR and PD in the non-squamous cell carcinoma after chemotherapy(p>0.05).The TC,HDL,and LDL indicators after chemotherapy in patients with efficacy evaluation SD were higher than those before treatment(p<0.05).Conclusion:Non-small cell lung cancer can affect blood lipid metabolism,and the change of blood lipid level can be used as an index to evaluate the curative effect and prognosis of chemotherapy in patients with non-small cell lung cancer. |
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