| Objective: Depression is a relatively common chronic psychiatric disease.However,with the introduction of the theory of fetal origin in adult diseases,there have been many studies that can prove that the pathogenic factors of many mental system diseases may appear in the fetus period.During the fetal period,due to various adverse stresses in the maternal intrauterine environment,it may cause elevated levels of glucocorticoids(GCs)in the fetus.Excessive GCs exposure can increase the risk of mental illness such as depression and anxiety in adulthood,and can be transmitted to the second generation through intergenerational inheritance.There is no safe and effective preventive measure for this intergenerational transmission.Recent studies have shown that mitochondrial dysfunction may be involved in the development of depression.At the same time,a series of studies have also shown that exercise can alleviate the symptoms of depression,but the mechanism is not clear.Therefore,this study will focus on whether the exercise can alleviate the generation of depression-like behaviors caused by excessive GCs in the maternal pregnancy and its intergenerational transmission,and study its mechanism to explore the role of mitochondria.Design: Firstly,a rat model of excessive exposure to GCs during pregnancy was constructed.After the offspring were extended to 4 weeks,the treadmill exercise training was given for four weeks.After the exercise intervention,the sugar water consumption experiment and forced swimming test were used to test the behavior change..At the end of the behavioral test,the F1 generation was cross-breeded into the F2 generation,and its behavioral changes were tested again after adulthood.At the end of the behavioral experiment,the F2 generation was sacrificed and the function of the mitochondria in the hippocampus was collected.Results: After the intervention of the first generation of exercise after the mother exposed to excessive glucocorticoids during pregnancy,compared with the non-exercise group,the exercise group significantly reduced the immobility time in the forced swimming experiment,and the syrup consumption ratio was significant in the saccharification preference experiment.Increase.The behavioral results of the second generation showed the same trend.The second generation of the sub-generational sports group achieved better results in forced swimming and sugar consumption experiments.The second generation of the sub-generational exercise group had better mitochondrial function than the second generation of the non-exercise group.The mitochondrial ROS production was significantly reduced,the mitochondrial ATP production was significantly increased,and the mitochondrial membrane potential was significantly increased.Conclusions: 1)Excessive exposure to glucocorticoids during pregnancy may result in depression-like behavior in offspring,and exercise may alleviate the depression-like behaviors that result from it.2)Exercise can improve depression-like behavior in offspring of depressive-like behavior.3)Depression-like behavior may be related to damage of mitochondrial function in the hippocampus of the brain,and exercise can improve mitochondrial function. |
