Short-term Prognostic Evaluation Of RhBNP In The Treatment Of Acute ST-segment Elevation Myocardial Infarction

Objective:To observe the effects of recombinant human brain natriuretic peptide(Recombinant Human Brain Natriuretic Peptide,rhBNP)on cardiac function and short-term prognosis in patients with acute ST-segment elevation myocardial infarction(ST-Segment Elevation Myocardial Infarction,STEMI)after emergency percutaneous coronary intervention(Percutaneous Coronary Intervention,PCI).To investigate whether rhBNP can inhibit ventricular remodeling after acute ST-segment elevation myocardial infarction and explore its mechanism.Methods:A total of 68 patients with acute ST-segment elevation myocardial infarction who underwent PCI in our hospital were selected as subjects.According to clinical medical conditions and patient wishes,the two groups were divided into control group(n=38)and treatment group(n=30).The control group received conventional drug therapy,and the treatment group was combined with neonatal injection for 3-7 days on the basis of conventional drug therapy.Blood samples were taken,and myocardial enzymes and myocardial fibrosis serological markers were detected during hospitalization to assess cardiac function.Two-dimensional echocardiography was used to determine end-diastolic diameter(LVEDD),end-systolic diameter(LVESD),left ventricular ejection fraction(LVEF)and peak-to-E peak velocity ratio(E/A).Follow up the above-mentioned cardiac function indicators in the day of surgery,January,March,and June of the two groups.and occurrence of the major adverse cardiac events(Major Adverse Cardiovascular Events,MACE).Results:The differences of LVEDD,LVESD,LVEF and E/A between the two groups at admission,January,March and June were significant(P<0.05),and there was no statistical difference in the group(P>0.05).In addition,the incidence of acute heart failure in the treatment group washigher than that in the control group(P<0.05).Conclusion:rhBNP treatment can improve diastolic function in patients with STEMI after emergency PCI,improve ventricular remodeling and short-term prognosis and prevent heart function deterioration.To some extent,it can prevent systolic dysfunction and myocardial fibrosis.