Clinical Study On The LSM And FIB-4 Values Of Qebaogangao Combined With ETV In Hepatic Fibrosis Patients With Liver Depression And Spleen Deficiency

Objective:By exploring the changes in LSM and fib-4 values of Qebaogangao combined with ETV in the treatment of liver fibrosis patients with liver depression and spleen deficiency,the therapeutic effect of this treatment scheme on anti-fibrosis was verified,providing a new idea for the anti-fibrosis scheme.Methods: Choose between January 2017 and January 2019 in our hospital for the first time change the type of hepatitis B patients with liver fibrosis,to perfect the research laboratory,participants included 60 patients as the research object,its randomly divided into control group(ETV monotherapy)30 cases and treatment group(ETV combined with Qebaogangao therapy)30 cases,two groups of 48 weeks of treatment,LSM value,FIB-4 value,ALT,AST,TBIL,HBV DNA value,hepatic fibrosis score at 0,24 and 48 weeks were observed,and the data were collected for statistical analysis.Results:(1)After 24 weeks of treatment,the LSM value,FIB-4 value,HA,LN,CIV,PIIINP,ALT,AST and TBIL values in the treatment group and the control group all decreased compared with that at 0 weeks,and the difference between the two groups was statistically significant(all P<0.05).After 48 weeks after treatment,the treatment group and control group of LSM value,FIB-4,HA,LN,CIV,PIIINP,ALT,AST,TBIL group more than 0 there is a decrease in the weeks and 24 weeks,compared with 0 weeks between groups,a significant reduction in the treatment group than the control group,the difference was statistically significant(P<0.05),compared with 24 weeks between groups,the treatment group than the control group no significant decline,there was no statistically significant difference(P>0.05);(2)After 24 weeks treatment,the treatment group compared with the control group of patients with general curative effect,Chinese medicine symptom curative effect have obvious difference,the difference was statistically significant(P<0.05),after 48 weeks after treatment,the treatment group compared with the control group of patients with general curative effect,Chinese medicine symptom curative effect have obvious difference,the difference was statistically significant(P<0.05);(3)After 24 and 48 weeks of treatment,there was no significant difference in HBV DNA negative conversion rate between the treatment group and the control group(P>0.05).Conclusion:The combined treatment of Qebaogangao and ETV with traditional Chinese and western medicine is more effective than western medicine in reducing the value of LSM and FIB-4 in liver fibrosis patients with liver depression and spleen deficiency,which is worthy of further study.