Through The Study Of The Expression Of IL-4,5,6,and TGF-?1 In Serum,the Mechanism Of Action Of Xingqiao Decoction On Chronic Rhinosinusitis Without Polyps After Operation Was Investigated

Research purposes:The purpose of this study was to investigate the mechanism of action of Xingqiao Decoction in the treatment of chronic rhinosinusitis without polyps(CRS s NP)and its effects on IL-4,5,6 and transformation during preoperative and postoperative inflammatory response.The effect of growth factor TGF-?1,followed by the mechanism of action of awakening soup on the inflammatory response of CRS s NP.Xingqiao Decoction is the protocol of otolaryngology in our hospital.It has been used clinically for more than 20 years.Relevant research shows that the clinical efficacy of Xingqiao Decoction combined with western medicine in treating CRS is better than that of western medicine alone,which further proves the superiority of Xingqiao Decoction compared with Western medicine.Sex[1].At the same time,the study showed that Wake Decoction has obvious advantages for postoperative mucosal remodeling of CRS[2].However,its mechanism of action is still unclear.Therefore,it is meaningful to further study its mechanism of treatment of CRS as a basis for the clinical promotion of traditional Chinese medicine.Research method:During the period from March 20 to November 2018,40 patients with chronic rhinosinusitis without polyps(CRS s NP)were diagnosed and required endoscopic surgery.Patients were randomly divided into two groups,20 in the control group and 20 in the treatment group.The control group was treated with endoscopic surgery and routine perioperative management.The treatment group remained unchanged during the operation period,and was treated with Xingqiao Decoction(provided by the hospital preparation)to replace oral clarithromycin.One dose per day was administered orally twice a day,from the first two weeks before surgery to 12 weeks after surgery.In this topic,1 week before surgery and 12 weeks before surgery,the visual analogue scale was used to evaluate the subjective symptom scores,and combined with the quantitative evaluation method of nasal endoscopy(Lund-Kennedy score),comprehensive evaluation of the two treatment methods Clinical efficacy.In addition,we selected the serum obtained freshly or frozen in liquid nitrogen 1 week before surgery and 12 weeks after surgery,and detected IL-4,5,6 and transformation growth in serum samples by enzyme-linked immunosorbent assay(ELISA kit).The expression level of factor ?1(TGF-?1).Result:1.At 12 weeks after operation,the treatment group and the control group compared the four subjective symptom scores of purulent sputum,nasal congestion,headache and olfactory decline and the sum of the four subjective symptom scores,which were consistent with the normal distribution.The treatment group was significantly better than the control group.Group,the difference was statistically significant(P<0.05).2.The control group and the treatment group were scored according to the Lund-Kennedy score method for the endoscopic mucosal state at 12 weeks after surgery.Because the patients with chronic rhinosinusitis(without polyps)were selected,the polyps were not treated.In addition to polyps,the scores of edema and rhinorrhea were compared with the sum of the four scores(P<0.05).The difference was statistically significant,and the scores of scar and scar were compared.The difference did not exist.Statistical significance(P>0.05)?it can be seen that the therapeutic effect of the treatment group in edema and rhinorrhea is significantly better than the control group.3.According to the clinical efficacy evaluation standard,the total effective rate of the treatment group and the control group were 95%and 75%,respectively,and the cure rate was 90%and 60%,respectively.The total effective rate and cure rate of the two groups were compared.The total effective rate was compared(P>0.05).There was no statistical value.The cure rate of the treatment group was significantly higher than that of the control group.The treatment group was more effective than the control group.Serum was taken by enzyme-linked immunosorbent assay(ELISA kit)1 week before surgery and 12 weeks after surgery.The therapeutic groups were lower than IL-4,5,6 and transforming growth factor ?1(TGF-?1).In the control group,the difference was statistically significant(P<0.05).Conclusion:The use of Xingqiao Decoction in patients with CRS s NP during perioperative period can effectively improve the subjective symptoms and promote the recovery of postoperative nasal mucosa.In particular,it can effectively eliminate inflammation,inhibit the secretion of nasal pathological secretions,and reduce postoperative mucosal edema.The situation,in order to achieve the purpose of improving nasal ventilation and drainage.It also significantly reduced the expression levels of IL-4,5,6 and transforming growth factor ?1(TGF-?1)in serum samples.This study confirmed that patients with CRS s NP have a certain treatment during the perioperative period of endoscopic surgery.The advantages are significant in clearing the inflammatory response and provide a clinical basis for the further application of Chinese medicine in the perioperative period.