Correlation Between Dipeptidyl Peptidase-4 High-sensitivity C-reactive Protein And Severity Of Coronary Artery Disease

Objective:To discuss the connection among the level of plasma dipeptidyl peptidase-4,high-sensitivity C-reactive protein and the degree of coronary artery lesion,and to find new indicators for predicting the degree of coronary artery stenosis.Methods:Patients who accepted coronary angiography at the Department of Cardiology,Yanbian University Affiliated Hospital from March 2017 to December 2017 were enrolled.Selection criteria:At least one vascular stenosis degree?50%was diagnosed as coronary heart disease,the degree of vascular stenosis<50%was coronary negative.120 patients with coronary heart disease were collected.Calculate the SYNTAX score based on the results of coronary angiography,the coronary heart disease group was further divided into low-risk,middle-risk and high-risk patient groups.40 patients showing negative coronary angiography results were included in the control group.Collecting patients' age,gender,smoking history,medication history(hypertensive drugs,insulin,statins,antiplatelet drugs)and past medical history(hypertension,diabetes,lipids abnormalities,history of myocardial infarction,percutaneous coronary intervention or heart bypass surgery,cerebrovascular disease history).Plasma levels of glycated hemoglobin,low-density lipoprotein cholesterol,high-density lipoprotein cholesterol,total cholesterol,triglycerides,serum creatinine,high-sensitivity C-reactive protein and dipeptidyl peptidase-4 were measured in all enrolled patients.Statistical analysis.Results:1.Gender and age comparison:The proportion of women in the low-risk group and the middle-risk group of coronary heart disease was lower than that in the control group,and the difference was statistically significant(P<0.01).The age of each group in coronary heart disease was higher than that in the control group,and the difference was statistically significant(P<0.05).2.Comparison of past medical history:Both the control group,low-risk group,middle-risk group and high-risk group,the prevalence of hypertension increased with the severity of coronary artery disease(P<0.05).3.Comparison of medication history:The history of ?-blockers in the middle-risk group and high-risk group of coronary heart disease was higher than that in the control group,the difference was statistically significant(P<0.05),and with the severity of coronary artery disease,the increase in the use of ?-blockers has also increased.The history of previous insulin use and the history of angiotensin converting enzyme inhibitors increased with the severity of coronary artery disease(P<0.05).4.The serum creatinine level in the high-risk group of coronary heart disease was higher than that in the control group,the difference was statistically significant(P<0.05),and increased with the severity of coronary artery disease.The low-density lipoprotein cholesterol levels in the low-risk group and the high-risk group were higher than those in the control group 5the difference was statistically significant(P<0.05),and increased with the severity of coronary lesions(P<0.01).5.The high-sensitivity c-reactive protein level in the low,middle and high-risk groups of coronary heart disease was higher than that in the control group.The high-sensitivity c-reactive proteinl level in the middle-risk group was higher than that in the low-risk group(P<0,05),the difference was statistically significant,and increased with the severity of coronary artery disease(P<0.001).6.The dipeptidyl peptidase-4 in high-risk group and middle-risk group of coronary heart disease was higher than the control group,low-risk group,the difference was statistically significant(P<0.05).The level of dipeptidyl peptidase-4 in high-risk group was higher than that of the middle-risk group,the difference was statistically significant(P<0.05),and increased with the severity of coronary lesions(P<0.001),7.Multiple linear regression analysis of hs-CRP and dipeptidyl peptidase-4 levels affecting the degree of coronary artery disease:high-sensitivity c-reactive protein and dipeptidyl peptidase-4 levels were positively correlated with SYNTAX scores when unadjusted,and B values were 0.339 and 0.001.After adjusting for age,gender,myocardial infarction history,?-adrenergic block agents medication history,angiotensin converting enzym medication history,serum creatinine,low density lipoprotein cholesterol factors,high-sensitivity c-reactive protein was still positively correlated with SYNTAX score.Conclusion:Plasma dipeptidyl peptidase-4 and high-sensitivity C-reactive protein levels were positively correlated with SYNTAX score in patients with coronary heart disease.