Correlation Between Serum TC,LDL And HDL Levels And Distant Metastasis Of Colorectal Cancer

Objective: To explore the correlation between serum levels of Total cholesterol(TC),Low density lipoprotein(LDL)and High density lipoprotein(HDL)with distant metastasis in colorectal cancer patients,and the clinical value of the results in the diagnosis and treatment of colorectal cancer patients.Methods: In this study,a retrospective study was conducted on the complete clinical data of 220 patients who received surgical treatment for colorectal malignant tumors from October 2016 to December 2018 in gastrointestinal surgery department of the second affiliated hospital of dalian medical university.General statistical indicators include: gender,age,anemia(according to the actual situation,combined with previous research data,according to whether the patient has anemia and anemia degree,the included cases can be divided into no anemia group cases,mild to moderate anemia group cases,severe anemia group cases),whether there is hypertension.Clinical indicators include TC(total cholesterol in serum),LDL(low density lipoprotein in serum),HDL(high densitylipoprotein in serum)and Alb(albumin in serum).The patients were divided into the > 35g/L case group and the 35g/L case group with a critical value of 35g/L.Relevant indicators of tumor characteristics include: tumor location,degree of tumor differentiation,pathological type of tumor,vascular invasion,lymph node metastasis and distant metastasis.All measurement data in this study were expressed in the form of mean standard deviation,and SPSS17.0 software system was used for data processing.To study the relationship between distant metastasis of colorectal cancer and gender,age,anemia,hypertension,location of tumor,degree of tumor differentiation,pathological type of tumor,vascular invasion and lymph node metastasis,the chi-square test was used to detect the correlation.P < 0.05 was considered statistically significant.For the two groups with or without distant metastasis of colorectal cancer,there was a significant difference in serum lipid level between the two groups.T-test and mann-whitney test were used for comparison between the two groups,and P < 0.05 was considered statistically significant.To investigate the relationship between distant metastasis of colorectal cancer patients and serum low density lipoprotein(LDL),high density lipoprotein(HDL)and total cholesterol(TC).According to the data analysis results,the correlation between TC,LDL and HDL levels in serum and distant metastasis of colorectal cancer patients was discussed,and the clinical value of the results in the diagnosis and treatment ofcolorectal cancer patients.Results: 1.Colorectal cancer patients with or without distant metastasis showed no difference in gender(p=0.133),age(p= 0.938),anemia(p=0.111),hypertension(p=0.081),serum albumin level(p=0.899),tumor location(p=0.477),pathological type(p=0.577),etc.2.Patients with distant metastasis of colorectal cancer compared with patients with distant metastasis of colorectal cancer,the degree of tumor differentiation(p = 0.038),and whether tumor vascular invasion(p = 0.034),if there is a cancer tumor nodules(p = 0.043),and whether tumor with lymph node metastasis(p = 0.029),serum TC(p =0.003),HDL(p = 0.001),LDL(p = 0.003),differences exist;Among them,compared with patients without distant metastasis,patients with colorectal cancer have higher serum TC and LDL levels,but lower HDL levels.Conclusion: 1.The presence of distant metastasis in colorectal cancer is closely related to the levels of TC,LDL and HDL in serum.2.Serum TC and LDL levels were higher in colorectal cancer patients with distant metastasis,while serum HDL levels were lower in patients without distant metastasis.3.Monitoring blood lipid level has certain reference significance for the detection of colorectal cancer.