Analysis Of The Effect Of Percutaneous Nephrolithotomy On Early Renal Function In Patients With Complicated Renal Calculi

Objective: To investigate the effect of percutaneous nephrolithotomy on the treatment of early renal function in patients with complicated renal calculi and to evaluate the risk factors for postoperative renal function deterioration.Methods: Seventy-seven patients with complicated renal calculi who underwent percutaneous nephrolithotomy in our hospital were divided into patients with normal renal function(serum creatinine <115 ?mol·L-1)according to preoperative baseline renal function(group A).Patients with abnormal renal function(serum creatinine ?115?mol·L-1)(group B),each group was divided into single access tract group(number of access tracts= 1)and multiple access tracts group(number of access tracts? 2)according to the number of access tracts.Record serum creatinine and other indicators of renal function before and 24 hours after surgery.At the same time,rsome factors that may affect the changes of renal function were recorded and evaluated.Results: In group A,There are multi-channel patients who postoperative cystatin C levels were higher than those before surgery.The difference was statistically significant(P<0.05).Other indicators remained almost steady(P>0.05).In group B,single access tract patients were similar to group A,and each index remained basically stable(P>0.05).The levels of serum creatinine and cystatin C increased significantly after multiple access tracts patients,and the estimated glomerular filtration rate decreased significantly(P<0.05).Independent risk factors leading to deterioration of renal function include preoperative high concentrations of serum creatinine,multiple access tracts,diabetes,and hypertension.Conclusion: Multiple access tracts PCNL has a significant effect on early renal function in patients with renal insufficiency.Preoperative renal injury,diabetes and hypertension are potential risk factors for renal dysfunction.