The Distribution And Antibiotic Sensitivity Of Pathogens In Infections After Artificial Joint Replacement

Objective: To review the type and number of pathogens and their antibiotic sensitivity in patients with infected artificial joint replacement in order to offer some data for diagnosis and treatment.Methods: Totally 205 cases of patients with infections after artificial joint replacement from Aug.2010 to Dec.2016 were chosen as research objectives.The distribution of pathogens and antibiotic sensitivity of 205 cases of infected patients after artificial joint replacement were retrospectively analyzed.Results: pathogens were isolated from 118 patients,the positive culture rate was 57.56%,the negative culture rate was 42.44%.Totally 133 strains were isolated,including 88 strains of gram-positive bacteria(66.17%)and 32 strains of gram-negative bacteria(24.06%),13 strains fungi isolates(9.77%).The most common causative organism of infection was Staphylococcus aureus(24.81%),and followed by Staphylococcus epidermidis(21.05%).Gram-negative bacteria were dominated by Klebsiella pneumoniae(3.76%)? enterobacter cloacae(3.76%)and Escherichia coli(3.01%).The results of antibiotic sensitivity showed penicillin ? clindamycin ? erythrocin and oxacillin were poorly susceptible to major pathogens.The highest drug resistance rates were 96.43%.Some antibiotics such as vancomycin,linezolid and tigecycline had high rates of drug sensitivity(100%).Conclusion:carbapenems antibiotics to cover gram-negative bacteria,vancomycin to cover gram-positive bacteria,vancomycin and levofloxacin to cover uncertain bacteria.