| Objective To evaluate the clinical effect and safety of capecitabine combination chemotherapy for advanced pancreatic cancer.Methods The Cochrane Library,PubMed,EMbase,CBM,CNKI and WanFang Data were searched to collect randomized controlled trials(RCTs)on capecitabine combination chemotherapy for advanced pancreatic cancer from inception to Dec,2017.Two reviewers independently screened literature,extracted data and assessed the risk of bias of included studies.Then,data were analyzed by using RevMan 5.3 software.Results One thousand and three hundred seventeenpatients with advanced pancreatic cancer were selected.Compared with control,capecitabine combination chemotherapy extended the overall survivaland disease progression-free survival.Moreover,the objective response ratewas significantly increased in capecitabine combination chemotherapy.The results of 3-4 toxic side effects of 6 RCT indicated that the incidence of neutropenia,stomatitis and hand-foot syndrome of capecitabine combination chemotherapy were obviously higher than those in the control.Conclusions Capecitabine combination chemotherapy extended the overall survivaland disease progression-free survival,and improve the objective response rate. |
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