Clinical Features Of COPD With Lung Cancer

Objective:Chronic obstructive pulmonary diseases(COPD)and lung cancer are high-and high-mortality diseases in China and even in the world.Epidemiological studies have shown that they often coexist and interfere with each other's prognosis.The purpose of this study is to investigate the correlation between COPD and lung cancer,clinical features of COPD with lung cancer,and risk factors for COPD with lung cancer,so as to provide basis for the prevention,diagnosis,and treatment of this subgroup of COPD with lung cancer.Methods:A retrospective analysis was conducted to collect data on the inpatients of respiratory medicine,thoracic surgery,and general surgery,aged 40 years and with pulmonary function,from June 2016 to June 2017 in Qilu Hospital of Shandong University.Patients were divided into two groups according to whether or not they had lung cancer.The lung cancer group(observation group)and non-lung cancer group(control group)were divided into two groups according to whether the patient had COPD or not:45 patients with simple lung cancer,76 patients with COPD plus lung cancer,and 43 patients with COPD in the control group.No COPD in 166 cases.Collect the complete patient data of the above patients,record their general patient qualifications,such as gender,age,occupation,smoking history,past chronic disease history,and still need to record the tumor site,lung cancer staging,diagnosis methods,and treatment procedures for patients with lung cancer.For patients with COPD,the patient's medical history,pulmonary function,GOLD stage,and ingestion of corticosteroids were recorded.For retrospective analysis,data processing was performed using statistical software SPSS 23.0.Continuity measurement data were expressed in the form of mean±standard deviation.Classification count data were expressed in terms of rate.Measurement data were in normal distribution and t-test was used.Count data were analyzed using pearson.Chi-square test or fisher exact test was used for statistical analysis;risk factors were screened using logistic regression analysis.Set the test level ? = 0.05,P<0.05 for the difference was statistically significant.Results:].Age:The ages of COPD combined lung cancer group,simple lung cancer group,and COPD group were statistically different.The results showed that the COPD combined lung cancer group and COPD group had statistically different ages.COPD lung cancer group was younger than COPD group.There was a statistically significant difference in age between the simple lung cancer group and the COPD group.The simple lung cancer group was less than the COPD group age(P<0.001).There was no difference between the COPD lung cancer group and the simple lung cancer group.Further age grouping was divided into two groups:<60 years old and?60 years old.Patients with COPD combined lung cancer group ?60 years old were higher than those with simple lung cancer group(P<0.05);COPD combined lung cancer group and COPD group there was no statistical difference;the simple lung cancer group was less than the COPD group and there was a statistical difference.2.Smoking Index:The smoking status of the three groups of patients was divided into two groups according to the smoking index<400*year and ?400*years,showing that there was a statistical difference in the smoking index between the three groups,but there was no difference between the COPD lung cancer group and the COPD group and the simple lung cancer group.Statistically significant differences were found in the simple lung cancer group with a smoking index of ?400 cigarettes per year higher than in the COPD group.The difference was statistically significant.3.Inhaled hormone therapy:The statistics of inhaled glucocorticoids in COPD patients with lung cancer and COPD were statistically significant.Fisher's exact test showed that there was a statistically significant difference between them.COPD patients with inhaled glucocorticoids were more likely to have lung cancer than those with inhaled glucocorticoids.The risk is low(P<0.05);4.Pathological type and staging:The chi-square test was performed on pathological types and staging of COPD combined lung cancer and lung cancer.There were statistical differences between the two groups.The incidence of squamous cell carcinoma in the COPD combined lung cancer group was higher than that in the simple lung cancer group,and stratified by TNM staging.The analysis showed that patients with COPD with lung cancer were mostly in stage III and IV(P<0.05).5.Multivariate regression analysis of lung cancer risk factors such as age,gender,smoking,and history of COPD,COPD is a risk factor for lung cancer that is independent of other risk factors.Conclusions:1.Age>60 years is a risk factor for COPD with lung cancer.2.COPD lung cancer is mainly squamous cell carcinoma.3.COPD is an independent risk factor for lung cancer.For patients with COPD,attention should be paid to the screening of lung cancer during the development of the disease.4.The specification of inhaled corticosteroids can reduce the occurrence of COPD with lung cancer.