Research On Neural Mechanism Of Premature Erosion Based On Brain Structure Image

Premature ejaculation is a common male disease that not only undermines male self-esteem,but also affects marital relations and family harmony.In the early stage,studies on premature ejaculation focused on psychology and hormones,and found that patients with premature ejaculation were accompanied by anxiety and depression.A study of the male ejaculation process found that ejaculation is mainly controlled by the sympathetic nervous system and the somatic nervous system,indicating the importance of the nervous system in ejaculation.However,the current neural mechanism of premature ejaculation is still unclear.The emergence of structural magnetic resonance imaging technology provides a very convenient means for the study of the neural mechanisms of diseases.Although the technology of magnetic resonance imaging is very mature,there is a lack of research on premature ejaculation.In this thesis,structural magnetic resonance imaging is used to explore the neural mechanism of premature ejaculation patients,and the mechanism of the disease is understood from the perspective of neuroscience.It provides a basis and help for understanding the neural mechanism of premature ejaculation.Firstly,this paper collected the structural images of the patient group and the control group.Based on the existing imaging studies on premature ejaculation,compared with the control group,the cerebral cortex areas of premature ejaculation patients were extracted.Based on the different regions,the whole brain covariation linkage analysis was performed in this paper for the premature ejaculation patients.Secondly,the covariant-linked regions were selected as the regions of interest.Fiber tracing was used to reconstruct white matter fibers that passed through the covariant junction brain regions.The average diffusion rate,anisotropy fraction,radial diffusion coefficient,and axial diffusion coefficient of these white matter fibers were analyzed for the differences between the patient group and the control group,and the correlations between the fiber bundles and premature ejaculation related indicators and emotions were analyzed.Then,from the overall point of view,this dissertation constructs the structural network of premature ejaculation patients by using graph theory.It mainly uses the 90 brain regions of the auto-anatomical template as the nodes,and uses the whole brain fiber tracing as the edge to construct the structural network for network analysis;Finally,this paper studied the effects of morphological and diffuse characteristics of cerebral cortex on the classification of premature ejaculation patients and normal controls,extracted the morphological and diffuse characteristics of the cerebral cortex as a predictor,used lasso regression to perform dimensionality reduction,used the support vector machine model to classify premature ejaculation patients and normal subjects,and constructs different models through feature combination.The classification effect of each model is evaluated and the importance of the features is calculated.In the part of covariation,this paper found that there are covariant connections in the prefrontal gyrus between the prefrontal gyrus and some brain regions of the default network.These areas and cognitive control have a certain correlation with somatosensory perception.In comparison with the control group,it was found that the covariant junctions of these brain regions were significantly elevated.In related studies of fiber tracing,white matter fibers were found in the frontal gyrus and middle frontal gyrus of the covariation region.Although the white matter fiber bundle of the patient was not found to be damaged in the differential analysis,there was a correlation between the patient's white matter fiber and the patient's mood.In the analysis of the structural network,it is found that the structural network of premature ejaculation patients has small-world properties by calculating the relevant network properties.Compared with normal controls,it was found that there were differences in some of the network properties of premature ejaculation patients,and the importance of some nodes changed.In the study of the characteristic importance of classified patients and normal controls,it was found that not only the brain area-frontal middle gyrus,which was previously studied in relation to the prevalence of cerebral cortex thickness differences,but also brain areas different from the previous studies,such as the hippocampus and the frontal pole,were found.At the same time,some white matter fiber bundles that contributed to the classification of premature ejaculation patients and normal controls were found,mainly the posterior coronal beam and the internal capsule sacrum.The results of this paper show that the neural mechanisms of premature ejaculation are quite different from those of normal controls.There is a big problem in the interaction of brain regions in premature ejaculation patients.The emotions of premature ejaculation patients are different from those of normal controls,and the emotions of premature ejaculation patients are related to white matter pathways.Changes in some brain regions of premature ejaculation patients may lead to changes in the overall brain structure.Some morphological and diffuse features of the cerebral cortex contribute significantly to differentiating abnormal changes in patients with premature ejaculation.The characteristics of these neural mechanisms provide some help for the study of the mechanisms of subsequent premature ejaculation diseases.