| Neuroendocrine tumor is a kind of heterogeneous tumor originated from the peptide can neurons and neuroendocrine cells,which could occur in many human tissues and organs,such as gastrointestinal system,lung,liver,pancreas,bronchus,adrenal medulla,thyroid and other parts of the neuroendocrine tissues and cells.Gastrointestinal neuroendocrine tumor accounted for about 70% to 75% of all neuroendocrine tumors,and lung neuroendocrine tumor accounts for about 25%.Pancreatic neuroendocrine tumor(PNET)is usually analyzed separately because it is highly invasive and has different molecular biological behavior,function,prognosis and treatment characteristics compared with non-pancreatic neuroendocrine tumor.In China,its annual incidence is about 1 case in 100,000 people.Although its incidence is not high,its detection rate has been increasing in recent years due to advances in imaging and diagnostic procedures.The increasing number of patients with PNET also poses new challenges for doctors to diagnose and treat this disease.ObjectiveTo explore the clinical characteristics,diagnosis,pathological characteristics and treatment of PNET.Materials and methodsAccording to inclusion and exclusion criteria,a total of 35 patients with PNETadmitted to the department of hepatobiliary and pancreatic surgery of the first affiliated hospital of Zhengzhou University from February 2013 to February 2018 were collected.All patients were confirmed as PNET by pathological report.1.According to the function of PNET,patients were divided into functional group and non-functional group.According to the test of normality and homogeneity of variance test results,baseline categorical clinical parameters between functional group and non-functional group were compared by Student t test or Wilcoxon rank-sum test;qualitative data using chi-square test.2.The detection rates of PNET in color doppler ultrasonography,CT and MRI were compared by chi-square test.3.Chi-square test was used to compare the positive rates of CgA group and Syn group in PNET patients4.Univariate analysis was performed on the indicators that might affect the prognosis of PNET patients,and COX multivariate regression analysis was performed on the indicators with statistical differences.Results1.Among the 35 patients with PNET,there were 15 males and 20 females.The average age(45.71±7.04)years old,the average age of functional PNET patients(41.60±5.93)years old,and the average age of non-functional PNET patients(48.80±6.27)years old.2.Of the 35 patients confirmed by pathology,34 underwent color doppler ultrasonography,and 19 tumors were detected,with a detection rate of 55.9%.CT examination was performed in 32 cases,and tumor was detected in 26 cases,with a detection rate of 81.3%.MRI examination was performed in 31 cases,28 cases of tumor were detected,and the detection rate was 90.3%.3.The mean tumor size was(3.21±1.27)cm,and postoperative pathology confirmed PNET.The mean functional diameter was(1.90±0.28)cm and the mean non-functional diameter was(4.20±0.67)cm.There were 17 cases at G1 level,12 cases at G2 level,and 6 cases at G3 level.4.Postoperative follow-up was conducted in 33 cases,with an average follow-up of 33 months,including 1 case with recurrence and 5 cases with death.Multivariate analysis showed that WHO grade,TNM stage and presence or absence of distant metastasis were related to the prognosis of patients(P < 0.05).Conclusions1.The onset age of PNET in the non-functional group was higher than that in the functional group,and the tumor diameter was larger than that in the functional group.2.The PNET detection rate of CT and MRI was higher than that of color doppler ultrasound.3.The results of multivariate analysis suggested that WHO grade,TNM stage and presence or absence of distant metastasis were the factors affecting the prognosis of PNET patients. |
PDF Full Text Request