| Background:Lung cancer is the malignant tumor with the highest morbidity and mortality in China.It has a high degree of malignancy and is not easy to develop.Blood hypercoagulation induced by lung cancer is not only one of the important causes of death in lung cancer patients,but also seriously affects the development,metastasis and prognosis of lung cancer.This hypercoagulability often occurs within three weeks of the diagnosis of a malignancy,and the associated mortality is highest within one year of the diagnosis.Because it has no obvious symptoms,it is often ignored.Therefore,it is of great significance to pay attention to the changes of coagulation in newly diagnosed patients with lung cancer,early detection and timely adoption of effective anticoagulation therapy for effective treatment and long-term prognosis of lung cancer patientsObjectives:In this study,222 patients with newly diagnosed lung cancer were selected,including lung adenocarcinoma,lung squamous cell carcinoma and small cell lung cancer.To explore the related mechanism of coagulation abnormality and its relationship with clinical characteristics.It can cause the clinician to pay attention to the coagulation abnormality in the newly diagnosed lung cancer patients and provide the related examination and treatment for the patients in time.Research methods:The lung cancer group in this study collected 222 patients,who were newly diagnosed patients admitted to the tumor center of shandong provincial hospital from January 2017 to December 2018,including lung adenocarcinoma,lung squamous cell carcinoma and lung small cell carcinoma.There were 114 patients with lung adenocarcinoma,41 with lung squamous cell carcinoma,67 with lung small cell carcinoma,142 with male and 88 with female,with an average age of 57.A total of 121 patients in the control group were non-tumor patients admitted in the same period.Coagulation parameters such as PLT,d-d,PT,APTT and Fib were collected from the two groups.Patients with lung cancer were divided into different groups according to the pathological type,stage,primary location and age of patients,and the coagulation indexes were compared.SPSS 22.0 software was used to process the data.P<0.05 indicated a significant difference between the two groups.P<0.01 indicated that there was significant difference between the two groups.Results:1.Comparison of abnormal number and abnormal rate of coagulation parameters between lung cancer group and control groupCompared with the control group,the total abnormal clotting rate,PLT,d-d,APTT and FIB were significantly increased in patients with lung cancer(P<0.05).This suggests that coagulation abnormalities are common in patients with lung cancer,mainly manifested in changes in d-d,FIB,PLT and APT levels.2.Comparison of coagulation parameters between lung cancer group and control groupCompared with the control group,PLT,d-d,PT,APTT and FIB levels in lung cancer patients all increased significantly(P<0.01),while TT levels showed no change(P>0.05).Conclusion:coagulation abnormalities are common in lung cancer patients.Such abnormalities may manifest as hypercoagulability(increased PLT,d-d,and FIB)or bleeding tendency(increased PT,APTT).3.Comparison of coagulation parameters between small cell lung cancer,non-small cell lung cancer and control groupCompared with the control group,PLT,d-d,PT,APTT and Fib levels were increased in patients with non-small cell lung cancer(P<0.05).Compared with the control group,PLT,d-d and Fib levels were increased and significant(P<0.05),but PT and APTT were not changed(P>0.05).There was no significant change in coagulation parameters between patients with small cell lung cancer and patients with non-small cell lung cancer(P<0.05),suggesting that the change of coagulation index in patients with lung cancer was unrelated to the pathological type of lung cancer.4.For small cell lung cancer:comparison of coagulation parameters between local limited period,extensive period and control groupCompared with the control group,PLT,d-d and Fib levels were increased in patients with locally limited small-cell lung cancer(P<0.05).Compared with the control group,PLT,d-d and Fib levels were increased in patients with extensive small-cell lung cancer,and the changes were significant(P<0.01).Compared with patients with extensive small-cell carcinoma,patients with locally limited small-cell carcinoma showed significantly higher d-d level and significant changes(P<0.01),while PLT and Fib levels showed no changes(P>0.05).The change of d-d level was related to the staging of small cell lung cancer.With the increase of staging,the increase of d-d was more obvious.5.For non-small cell lung cancer:comparison of coagulation parameters in non-stage IV,stage IV and control groupsCompared with the control group,PLT,d-d,APTT and Fib levels were all increased in patients with non-stage IV lung cancer,and the difference was significant(P<0.05),while PT was not changed(P>0.05).Compared with the control group,PLT,d-d,PT,APTT and Fib levels were significantly increased in patients with stage IV lung cancer(P<0.01).The d-d level of stage IV lung cancer was significantly higher than that of non-stage IV lung cancer,and the difference was significant(P<0.01),but the levels of PLT,PT,APTT and Fib were not changed(P>0.05).The change of D-D level was related to the stage of non-small cell lung cancer.With the increase of staging,the increase of d-d was more obvious.6.Comparison of coagulation parameters between left lung cancer group,right lung cancer group and control groupCompared with the control group,PLT,d-d,APTT and Fib levels increased in patients with left lung cancer(P<0.05).There was no significant change in PT level(P>0.05).Compared with the control group,PLT,d-d,PT,APTT and Fib levels increased in patients with right lung cancer(P<0.05).There was no significant difference in all coagulation parameters between the left lung cancer patients and the right lung cancer patients(P>0.05).The results showed that the changes of coagulation parameters were not related to the primary site of lung cancer.7.Comparison of coagulation parameters between different genders in patients with lung cancerPLT and d-d levels of female patients were higher than that of male patients,while Fib levels were slightly lower than that of male patients,and the difference was statistically significant(P<0.05).It can be seen that PLT and d-d levels increased more significantly in women with lung cancer,while Fib levels increased more significantly in men with lung cancer.8.Different age groups in lung cancer:comparison of coagulation parameters in group 60 + and group 60-APTT level and Fib of lung cancer patients aged more than 60 years were significantly increased compared with lung cancer patients aged less than 60 years(P<0.05).It indicates that APTT and Fib levels of lung cancer patients increase more significantly with the increase of age.Conclusion:1.Coagulation parameters of patients with lung cancer were abnormal to different degrees,mainly presenting changes in PLT,d-d,PT,APTT and FIB levels.2.The abnormality of coagulation index is significantly related to the occurrence,staging,gender and age of lung cancer,but not to the pathological type and primary site of lung cancer. |
PDF Full Text Request