Analysis Of Clinical Features Of Patients With Influenza-associated Guillain-Barre Syndrome In Southwest Shandong

Objective:Serum was tested in 150 patients with Guillain-Barre syndrome.To summarize the clinical characteristics of 150 patients and the clinical characteristics of serum influenza A virus antibody and influenza B virus antibody positive patients,compare the clinical characteristics of influenza virus-related GBS and non-influenza virus-related GBS patients,and provide evidence for the diagnosis and treatment of GBS.Methods:Retrospective collection General clinical data of 150 patients with GBS admitted to the Affiliated Hospital of Jining Medical College from October 2013 to June 2017,including gender,age,pre-infection,clinical manifestations,blood anti-ganglioside antibodies,mechanical ventilation,treatment.Serological tests of influenza A virus(IgA,IgG,IgM)and influenza B virus(IgA,IgG,IgM)were performed in 150 patients with GBS by enzyme-linked immunosorbent assay(ELISA).To summarize the clinical features of influenza A-related GBS,in:fluenza B-related GBS,and non-influenza A/B-related GBS patients;The chi-square test was used to compare the clinical characteristics of influenza A/B-related GBS in the region and influenza A/B-related GBS in foreign;The clinical features of influenza virus-associated GBS and GBS related to Campylobacter jejuni were compared.Result:There was no significant difference in gender ratio between influenza A-related GBS,influenza B-related GBS,and non-influenza A/B-related GBS(P=0.611);Influenza A-related GBS,influenza B-related GBS,and non-influenza A/B-related GBS had no significant differences in prodromal symptoms(P=0.956);Influenza A-related GBS,influenza B-related GBS,and non-influenza A/B-related GBS had no significant differences in neurological symptoms(muscle strength,facial paralysis,and medullary paralysis)(P=0.563,P=0.260,P=0.866);There was no significant difference in influenza A-related GBS,influenza B-related GBS,and non-influenza A/B-related GB S in whether or not mechanical ventilation was required(P=0.309);Influenza A-related GBS,influenza B-related GBS,and non-influenza A/B-related GBS had no significant difference in ganglioside antibody type(P=0.144).Influenza A-related GBS,influenza B-related GBS,and non-influenza A/B-related GBS were not significantly different in GBS subtypes(P = 0.224).There was no significant difference in the prodromal symptoms between the influenza A/B-related GBS in the region and influenza A/B-related GBS in the foreign(P=0.371,P=0.441).There was no significant difference in the neurological performance between the influenza A/B-related GBS in the region and the foreign influenza A/B-related GBS in the foreign(P=0.201,P=0.53 7).There was a significant difference in the pre-infection of GBS associated with influenza virus-related GBS and Campylobacter jejuni in this region(P=0.001).Age was significantly different for different pathogen-related GBS(P=0.029).Influenza virus-related GBS and Campylobacter j ejuni related GBS had significant differences in the number of ganglioside antibodies(P =0.011).Conclusion:Influenza-associated GBS and non-flu-related GBS had no significant differences in clinical characteristics(gender,prodromal symptoms,neurological symptoms,mechanical ventilation,ganglioside type,GBS subtype);There was no significant difference in clinical characteristics between the influenza A/B-related GBS in the region and influenza A/B-related GBS in the foreign;Patients with influenza-associated GBS are more likely to have upper respiratory tract infections,and patients with Campylobacter jejunal-associated GBS are more likely to have diarrhea;The proportion of influenza-associated GBS in patients older than 35 years was higher than that of Campylobacter j ejuni-related GBS;Influenza-associated GBS and Campylobacter jejuni related GBS have significant differences in the pathogenesis of ganglioside antibodies.