Correlation Study Of Post-stroke Anxiety,Post-stroke Depression And Mild Cognitive Impairment

Objective: To investigate the incidence and influence factors of PSA/PSD and mild cognitive impairment in after stroke.As well as relationships.Methods: From December 2017 to January 2019,98 patients with initial strokes who were admitted to the first hospital in Handan City First Hospital were selected as the study subjects.and it onset time less than two weeks.Clinical data were collected and analyzed.During the stay in hospital,MMSE,MoCA and HAMA,HAMD were measured at one time.According to the guidelines for the diagnosis and treatment of dementia and cognitive impairment in China(2015 edition),All MCI and cognitive normal people were identified and divided into two groups.Counting the incidence of anxiety,depression,and MCI in all post-stroke patients.In group MCI and group NCI,The incidence of anxiety and depression was calculated and compared.In addition,In addition,HAMA scores,HAMD scores and MoCA scores were compared and their relevance were explored.A logistic regression model is applied,Analyze the degree of education,labor way,smoking,drinking,diabetes,hypertension,anxiety,depression impact on patients with cognitive impairment after stroke.Results:(1)In post-stroke,51 cases of MCI were in total and accounting for52.0%.47 cases had normal cognitive function,accounting for 48.0%.75cases(76.5%)without anxiety;9 cases(9.2%)may had anxiety;12 cases(12.2%)had mild anxiety;2 cases(2%)had moderate anxiety;no severe anxiety.65 cases(66.3%)without depression;26 cases(26.5%)had mild depression;6 cases(6.1%)had moderate depression;1 case(1%)had severe depression.(2)In the MCI group,35 cases(68.6%)without anxiety,5 cases(9.8%)had possible anxiety,9 cases(17.6%)had mild anxiety,and 2 cases(3.9%)had moderate anxiety,and no severe anxiety.No depression28(54.9%),mild depression 16(31.4%),moderate depression 6(11.8%),severe depression 1(2.0%).In the NCI group,40 cases without patients anxiety(85.1%),4 cases may had anxiety(8.5%),3 cases had mild anxiety(6.4%),no moderate and severe anxiety.37 cases(78.7%)without depression,10 cases(21.3%)had mild depression,no moderate and severe depression.Two groups by Mann-Whitney U test,the difference with statistical significance.and(P < 0.05).(3)In the MCI group,MoCA scores,HAMD scores,HAMD scores were(14.51±4.115),(17.39± 4.285),(8.55±5.934).In the NCI group,MoCA scores,HAMD scores,HAMD scores were(22.28±3.658),(14.28±3.084),(6.00±3.445).Two sets of data between a statistically significant difference(P < 0.05).(4)Pearson partial correlation analysis shows,Between HAMD scores,HAMA scores,and MoCA scores.their correlation coefficients are-0.461 and-0.390.Two sets of data between a statistically significant difference(P < 0.05).(5)Logistic regression analysis showed that PSD(OR=1.140,95%CI:1.006-1.291,P=0.039),PSA(OR=1.140,95%CI:1.006-1.291,P=0.039)and hypertension(OR=3.397,95%CI:1.101-10.482,P=0.033)is an risk factor for MCI,and mental work(OR=0.233,95%CI=0.074-0.728,P=0.012)is a protective factor.Conclusions:(1)There is a higher incidence of MCI patients in post-stroke.(2)There's a certain percentage of depression and anxiety in post-stroke patients.(3)The incidence of anxiety and depression in patients with MCI after stroke is higher than that in the group with normal cognition.There were differences in anxiety and depression between MCI group and NCI group.(4)There's a linear correlation between post-stroke MCI and PSD/PSA.PSD is more relevant than PSA.the more serious the PSD and PSA,the greater the likelihood of MCI.(5)PSD,PSA and hypertension are risk factors for mild cognitive impairment after stroke,and mental work is a protective factor for mild cognitive impairment after stroke.