Clinical Research Of 24-hour Ambulatory Blood Pressure Variability And Heart Rate Variability In Patients With Parkinson Disease

Objective:This study first evaluated cardiovascular autonomic function in patients with Parkinson’s disease（PD）,and further explored correlation between cardiovascular autonomic function and age of onset、duration of disease、Hoehn-Yahr staging（H-Y stage）、the Unified Parkinson’s Disease Rating Scale III score（UPDRS III）and the Scales of Outcomes in PD-Autonomic（SCOPA-AUT）in patients with PD.Methods:Forty patients with PD（PD group）and forty healthy controls（control group）were enrolled in the study,then two group patients were recording non-invasive 24h ambulatory blood pressure and 24h ambulatory electrocardiogram,then Comparative analysis Ambulatory Blood Pressure Variability（ABPV）and Ambulatory Heart Rate Variability（AHRV）indicators of two group,then scored the Hoehn-Yahr stage（H-Y stage）、Unified Parkinson’s Disease Rating Scale III（UPDRS III）、Scales for Outcomes in PD-Autonomic（SCOPA-AUT）,further study the factors affecting PD cardiovascular autonomic function.Result:The SDNN,RMSSD,RMSSD,HF,LF,LF/HF of the 24hAHRV indexs in the PD group were significantly lower than control group（both P<0.05）.Compared with the control group,the S_24h、S_n,and D_n of the PD group were significantly increased,and the S.Nocturnal Fall%、D.Nocturnal Fall%of the PD group were significantly slower（p<0.05）.The S.SDd、D.SDd、S.CVd and D.CVd of the PD group were significantly higher than control group（p<0.05）.Among the newABPV indicators,patients in the PD group have higher S.AVR、D.AVR、S.SDdn and D.SDdn（P<0.05）.HRV was negatively correlated with age at onset,HY stage,SCOPA-AUT score and UPDRSIII score;There was a negative correlation between nocturnal blood pressure rhythm and age,HY stage、UPDRS III score（P<0.05）.ABPV was positively correlated with disease duration.Conclusion:Patients with PD have cardiovascular autonomic dysfunction,which is characterized by significant slow in AHRV、increase in ABPV and decrease in nocturnal blood pressure rhythm,and PD cardiovascular autonomic dysfunction is associated with age at onset、duration of disease、severity of disease、severity of motor symptoms and autonomic dysfunction.