| OBJECTIVE:To observe the clinical effect of Jisong No.1 combined with vertebroplasty in the treatment of osteoporotic vertebral compression fractures.METHODS:60 elderly patients with OVCF were selected from the Department of Orthopedics and Traumatology,Jiangsu Hospital of Traditional Chinese Medicine from October 2016 to March 2018.The symptoms of traditional Chinese medicine belong to the syndrome of deficiency of spleen and kidney yang.The selected cases were included in the diagnostic criteria of traditional Chinese and Western medicine.They were randomly divided into two groups:operation?anti-osteoporosis drug Gai Sanchun soft capsule(Qingdao Zhengda Pharmaceutical Company)combined with Calcium Erqi D(Wyeth Pharmaceutical Company)and operation plus anti-osteoporosis drug Gai Sanchun Soft Capsule(Qingdao Zhengda Pharmaceutical Company)combined with Calcium Erqi D(Wyeth Pharmaceutical Company).They were randomly divided into two groups,30 cases in each group.The same group of doctors underwent PVP operation.The experimental group was treated with Jigusong No.1 ?Gesanchun Soft Capsule(Qingdao Zhengda Pharmaceutical Company)and Calcium Erqi D(Wyeth Pharmaceutical Company).The control group was treated with surgery + Gesanchun Soft Capsule(Qingdao Zhengda Pharmaceutical Company)and Calcium Erqi D(Wyeth Pharmaceutical Company).There were 30 cases in the control group.The patients in the two groups were 56-88 years old,with an average age of(66.78+7.Fifty-three years old,including 19 males and 41 females,involved 60 cases of vertebral body,more than half of which were T11,T12,L1 and L2 fractures.Both groups were treated for one month after operation.RESULTS:1.There was no significant difference in preoperative general condition(age,sex),VAS score and ADL score between the two groups(P>0.05),and all patients had vertebral fracture for the first time.Both of them were comparable.VAS pain score was used to compare the detailed VAS scores of the two groups 3 days and 1 month after operation.There was no significant difference(P>0.05).The detailed VAS scores of the two groups 3 months and 6 months after operation were significantly different(P<0.05).The results showed that there was no significant difference in the short-term analgesic effect between the two groups,and the analgesic effect of the medium and long-term experimental group was better than that of the control group.2.Comparisons of adjacent vertebral fracture rates:3 days and 1 month after operation,there was no significant difference in vertebral fracture rates between the two groups(P>0.05).At 3 months and 6 months after operation,the incidence of vertebral fracture in the control group increased,and the difference was statistically significant(P<0.05).Further development of osteoporosis has resulted in re-fracture of adjacent vertebral bodies.Comparing the fracture rate of adjacent vertebral body between the two groups,there was a significant difference(P<0.05),indicating that in the long term,the treatment of the experimental group could reduce the recurrence rate of fracture of adjacent vertebral body compared with the control group.3.The ADL scores of the two groups increased significantly after 3 days of treatment,and there were significant differences before and after treatment(p<0.05).Compared with the control group,the ADL scores of the experimental group increased significantly after 1 month and 3 months of treatment(P<0.05).It shows that Spine Gusong No.1 can promote the functional recovery of patients after operation.4.Clinical evaluation of TCM symptoms:There was no significant difference between the two groups on the 3rd day and the 1st month after operation(P<0.05).There was significant difference in clinical efficacy between the two groups at 3 months and 6 months after operation(P<0.05).This shows that the experimental group is superior to the control group in clinical efficacy.5.Three days after operation,the gastrointestinal function of the two groups was compared.The stool of the experimental group was smooth and the appetite was strong within three days after operation.Constipation occurred in the control group.There was a significant difference between the two groups(P<0.05).CONCLUSION:Surgery combined with traditional Chinese medicine plus anti-osteoporosis drug Gai Sanchun soft capsule(Qingdao Zhengda Pharmaceutical Company)combined with Calcium Erqi D(Wyeth Pharmaceutical Company)in the treatment of OVCF can relieve gastrointestinal discomfort earlier.In the medium and long term,it is better to treat residual low back pain after operation than to take anti-osteoporosis drugs only after operation,and patients have better quality of life after operation.To see can effectively reduce the patient's adjacent vertebral fracture rate.Its curative effect can definitely be popularized and applied in clinic. |
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