Diagnostic Efficiency Analysis Of Single Lung Nodule With ¹⁸F-FDG And ¹⁸F-FLT PET/CT

Objective:To study and compare the Diagnostic efficiency of the two difference diagnostic method ¹⁸F-fluorothymidine(¹⁸F-FDG)and ¹⁸F-fluorodeoxiglucose(¹⁸F-FLT)PET/CT for single chest nodule.Methods:A total of 40patients found to be with chest nodules respectively using ¹⁸F-FDG and ¹⁸F-FLTPET/CT imaging,With pathologic results available and were followed up for 6 months after treatment.the receiver operating characteristic?ROC?curve was used to compare ¹⁸F-FDG SUVmax and ¹⁸F-FLT SUVmax methods for diagnostic value for breast malignant lesions;Two kinds of imaging results of¹⁸F-FDG SUVmax and ¹⁸F-FLT SUVmax were semi-quantitatively analyzed,and the different method diagnosis value was compared.Results:The area under the curve?AUC?of¹⁸F-FDG SUVmax and ¹⁸F-FLTSUVmax ROC was 0.689,0.801,respectively.Use ¹⁸F-FDG SUVmax,¹⁸F-FLT SUVmax and ¹⁸F-FLT SUVmax/¹⁸F-FDG SUVmax accuracy,sensitivity and specificity of SUVmax were calculated based on the condition that,the value of ¹⁸F-FDG SUVmax>2.5,the value of ¹⁸F-FLT SUVmax>1.4 and the value of ¹⁸F-FLT SUVmax/¹⁸F-FDG SUVmax>0.5.The results was 57.5%,88.2%,65.2%on ¹⁸F-FDG PET/CT imaging,75%,82.4%,69.6%on ¹⁸F-FLT imaging and 72.5%,47.1%,91.3%on¹⁸F-FLT SUV max/¹⁸F-FDG SUVmax.Conclusion:¹⁸F-FLT,which was able to reflect the characteristics of cell proliferation,as an agent of PET/CT imaging onclinical single lung nodules diagnosis could provide certain reference.