Related Factors Of Pregnancy Outcome In Patients With Low Ovarian Response After Frozen Embryo Transfer

Objective:Objective to explore the relationship between the related factors of frozen embryo transfer and pregnancy outcome in patients with low ovarian response.In order to better serve the majority of patients with low ovarian response,improve their clinical pregnancy rate.Methods:A retrospective study was conducted to analyze the clinical data of 160 patients(293 cycles)who underwent frozen embryo transfer(FET)in our center from January 1,2013 to December 30,2015.The clinical pregnancy outcomes were divided into clinical pregnancy group(115 cycles)and non pregnancy group(178 cycles).Age,body mass index,basic fsh,LH,T,E2 values,endometrial preparation,endometrial thickness at transplantation,E2,P,LH levels at transplantation,endometrial type at transplantation were compared between the two groups.Then,the patients were divided into<40 years old,? 40 years old according to the age group,and the influencing factors of different pregnancy outcomes in different age groups of patients with ovarian hyporesponsiveness were discussed.Single factor Logistic regression analysis was used to analyze the influencing factors of patients with low ovarian response.EpiData 3.0 was used for data management.The data of normal distribution continuous variables were represented by mean(+ SD),and the skewed distribution was represented by median(Median),25th percentile and 75th percentile(P25-P75).The two groups were compared by t test or Mann-Whitney U rank sum test according to whether the data conformed to normal distribution,and the percentage was compared by chi-square test.Statistical analysis was conducted using Yi Empowerstats software and R language.P<0.05 was statistically significant.Results:There was no significant difference in the pregnancy outcomes of hormone substitution,long-term GnRHa + hormone substitution,natural cycle and ovulation induction cycle in patients with ovarian hyporesponsiveness.The age of clinical pregnancy group was significantly younger than that of non-pregnant group.The number of high-quality embryos and E2 were higher than those of non-pregnant group.The type of endometrium and uterine cavity preparation before transplantation were also statistically significant(p<0.05)..Univariate logistic regression analysis showed that age,number of high quality embryos and type of endometrium were the influencing factors of pregnancy outcome in patients with ovarian hyporesponsiveness.In the age group<40 years old,the patient's age,endometrial type,basal E2,the number of high-quality embryos and uterine cavity preparation were statistically significant.The patient's age and high-quality embryos were independent influencing factors.FSH/LH was statistically significant for the group over 40 years old.FSL/LH was an independent factor for frozen embryo transfer.Conclusion:Patients with low ovarian response should undergo FET as early as possible.The plan can be chosen according to the basic condition of the patients.Selection of high-quality embryos as far as possible in patients with ovarian hyporesponsiveness younger than 40 years of age is conducive to improving pregnancy rate,while type A endometrium and preoperative uterine cavity preparation may help to improve clinical pregnancy rate;FSL/LH in patients with ovarian hyporesponsiveness younger than 40 years of age is negatively correlated with pregnancy rate,has a certain predictive effect on pregnancy rate,and appropriate increase of intimal thickness may be possible.It is beneficial to improve pregnancy outcome.