Value Of AMH In Assessing Long-term Effects Of Conventional IVF On Ovarian Function

Objective:The aim of the study is to explore the advantages of anti-Mullerian hormone(AMH)in evaluating the long-term effects of in vitro fertilization(IVF)on ovarian function.Methods:The study retrospectively analyzed infertility patients in our hospital who underwent the basic sex hormonal testing(interval with recent test>2 years)and had recent reliable blood AMH and basic sex hormonal testing data from November 2017 to March 2018.The patients were divided into two groups.The study group consisted of women who underwent conventional IVF at least 2 years interval with the recent test,while the control group consisted of comparable women who didn't experience IVF.In the condition of age,BMI,initial ovarian function,interval time(the primary test time to recent)in two groups comparable,compare the recent ovarian function(assessed by bFSH,AMH)in two groups to explore the advantages of anti-Mullerian hormone(AMH)in evaluating the long-term effects of in vitro fertilization(IVF)on ovarian function.Results:The effect of conventional IVF on ovarian function was related to age:Subgroup analysis showed that for>32 years old women,their recent ovarian function was significantly lower than those who did not receive IVF,and AMH values showed statistical difference(respectively 1.50±0.73 vs.2.60± 1.25,P=0.032).However,the similar outcomes didn't occur in non-subgroups.Besides,it was found that AMH was more advanced than bFSH in the assessment of ovarian function:AMH already showed significant difference between IVF and non-IVF females when bFSH didn't.Conclusion:Conventional IVF caused the acceleration of long-term ovarian function decline in women older than 32.For young women who had relatively stronger compensatory repair of ovary,the study of the effect of IVF on ovarian function needed expand sample size and extend follow-up time to further explore.AMH demonstrated better detective value than other indicators.For women who had received IVF treatment,the regular monitoring of serum AMH levels could earlier detect ovarian dysfunction,thus earlier take medical intervention to reduce the risk.