Analysis Of Common Pathogens In Periprosthetic Joint Infection And Testing Drug-resistance Rate For Different Antibiotics

Objective: 1.To analyze the common pathogens and their drug susceptibility results of Periprosthetic joint infection and to help select sensitive antibiotics and provide data support for the prevention and treatment of infections after artificial joint replacement.2.Analyze the differences in common infections between two different types of joint replacement(hip vs.knee),and the differences in the type of infection and the life span of the prosthesis.Methods: A total of 195 cases of peri-prosthetic joint infection were treated after prosthetic joint replacement in our hospital and Fuzhou Second Hospital from June 2011 to June 2017.Among them,143 cases were culture positive,52 cases were culture negative.The demographic characteristics were analyzed.For general data,a total of 133 strains of positive strains of pathogenic bacteria and susceptibility culture results were analyzed.Result: In the acute type of PJI,the proportion of knee anthroplasty is greater than hip anthroplasty.The main pathogens were Gram positive bacteria(123/157,78.34%).Staphylococcus aureus(36/157,22.93%)and Staphylococcus epidermidis(44/157,28.03%)also accounted for a large proportion.Bacteria were the most sensitive to vancomycin,forcezolidone and imipenem.The proportion of erythromycin,penicillin and compound sulfamethoxazole was high.Conclusion: In the acute type of PJI,the proportion of knee anthroplasty is greater than hip anthroplasty.Coagulase-negative bacteria are the most common bacteria that infect the prosthetic joints.Vancomycin,linezolid,and/or imipenem may be the first choice of treatment,then we can adjust some drugs based on bacterial drug sensitivity test.