A Case Of Chronic Myeloid Leukemia Myeloid Blast Crisis With NPM1 Mutation And Literature Review

Objective:To improve the understandingof Chronic Myeloid Leukemia with NPM1 mutation.Methods: By analyzing the clinical features,bone marrow cell morphology,immunology,cytogenetics,and molecular biology of one patient with CML-MBC,the author understood the difference between CML-MBC and AML further more,and realized the role of NPM1 in the progression and prognosis of CML and reviewed relevant literatures.Results:Through the follow-up of the patient in the past 1 year,it was found that by oral dasatinib treatment,the patient is always in the chronic phase of chronic myeloid leukemia(CML-CP),and the NPM1 gene is negative.Conclusion:NPM1 is a well-characterized gene mutation in AML.It may play a role in the progression of CML and may also have a beneficial effect on the prognosis of CML-MBC patients.It may be judged as one of the molecular markers of prognosis of CML-BC.