| Background: Chronic obstructive pulmonary disease(COPD)is a common disease of the respiratory system,and more convenient.And current treatment guidelines recommend inhaled bronchodilators in stable COPD as a first-line therapy.After treated with bronchodilators,which can effectively improve symptoms,but sometimes there is no significant changes in conventional pulmonary function,can not be completely comprehensive and stable,scientific evaluation of drugs in patients with stable COPD clinical efficacy.Therefore,the establishment of a reliable and sensitive indicator reflecting clinically stable COPD patient's condition and prognosis is very necessary.COPD patients after the onset of shortness of breath after the event mainly based,and shortness of breath and abnormal neural respiratory drive there is a close link.After the patient is treated,clinical symptoms will be effectively improved,suggesting that changes in respiratory center drive and ventilation /respiratory center drive ratio can be used as an important indicator to determine the patient's condition and evaluate the efficacy of the drug.Objective: To investigate the clinical effect of inhaled budesonide formoterol and its diaphragm EMG changes in the patient with COPD at rest.Methods: A total of 60 patients with stable COPD D were enrolled in the hospital from October 2016 to June 2017,the patients were diagnosed by imaging examination and detection of biochemical indexes for stable COPD,consistent with the 2013 Chinese society of respiratory diseases to develop standard guidelines for the diagnosis and treatment of COPD.According to different therapeutic measures,divided into control group of 30 cases and 30 cases in the observation group,the control group received routine treatment,observation group were treated with inhalation of Budesonide/Formoterol treatment,after 1 months of treatment,analysisof the application of SPSS19.0 statistical software,The lung function index,mMRC score,auxiliary respiratory muscle score and other indicators were observed after 1month.At the same time,electromyographic parameters of diaphragm were measured by CMAP and PNCT in two groups.Results: the two groups of patients before treatment the initial minute ventilation and respiratory parameters?EMGdi CMAP and PNCT was not statistically significant(P>0.05);the observation group after treatment,the value of EMGdi CMAP and PNCT was significantly lower(short)than the control group(P<0.05);auxiliary respiratory muscle score and mMRC score were observed after treatment was significantly lower than the control group(P<0.05);observation group of patients with clinical symptoms improved after treatment time was shorter than the control group(P<0.05);respiratory parameters of minute ventilation in patients in the observation group after treatment was significantly higher than that of the control group(P<0.05);There was no significant difference between the two groups in the treatment of lung function and 6-minute walking test results(P>0.05);the two groups of patients before lung function indexes had no difference Statistical significance(P>0.05);the lung function,FVC,FEV1,FEV1 Pred,FEV1/FVC and 6-minute walking test results in the observation group after treatment were higher than those in the control group(P<0.05).Conclusion: stable COPD patients treated with inhaled Budesonide/Formoterol therapy can improve the ventilation / respiratory drive ratio;strengthening electrode recording of diaphragmatic EMG detection(CMAPand PNCT)in the patients before and after treatment can reflect breathing center drive in the process of therapy in patients with COPD and thereby assessing clinical efficacy. |
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