Application Of Onodera's Prognostic Nutritional Index In The Evaluation Of Short-term Prognosis Of Pancreatic Cancer After Operation

Objective:The purpose of this study was to analyze the value of PNI index in assessing the short-term risks,including the risk of complications and death,in patients with pancreatic cancer after different operations.Methods:According to the different surgical methods,patients were divided into two groups:pancreaticoduodenectomy group(PD group)and non-pancreaticoduodenectomy group(non-PD group).The PNI index of each case was calculated according to the formula:PNI=ALB(g/L)+5*TLC(10~9/L).Divide the patients into eutrophy group(PNI?47)and malnourished group(PNI<47).General clinical data(Sex?Age?BMI?Diabetes history?Smoking and Drinking history),tumor and surgical data(Tumor size?Lymphonodus?Extrapancreatic invasion?Ca199?Preoperative total bilirubin?duration of operation?Postoperative hospitalized period),postoperative mortality and major complications(Pancreatic fistula?Intestine fistula?biliary fistula?Thoracic complications?Hemorrhage?Abdominal cavity infection?Wound infection)were collected and compared between the two groups.The enumeration data of two groups were compared by chi-square test and the measurement data by t-test.Results:There were 34 patients in PD group,17 case in eutrophy group and 17 in malnutritiongroup.AmongGeneralclinicaldata,thetwogroupswasno difference,neither in tumor and surgical date between the two groups.The patients with complications in the two groups were 6 and 14 case(P=0.013).A separate analysis of the complications revealed that the risk of chest complications is greatly different(2 and 9case,P=0.026).There were 26 patients in non-PD group,16 case in eutrophy group and 10in malnutrition group.Among General clinical data,the two groups was no difference.The postoperative hospitalized period of the two groups were 17.00±6.94 and 23.50±8.21days(P=0.040),There was no difference in other tumor and surgical data between the two groups.The patients with complications in the two groups was 5 and 8 case(P=0.041).A separate analysis of the complications revealed that the risk of chest complications is greatly different(P=0.014).Conclusion:PNI is a convenient nutritional evaluation index,which can effectively predict the risk of postoperative complications in patients with pancreatic cancer,but the value of PNI in assessing the risk of death and other complications except chest complications is unclear.