A Preliminary Study On The Feasibility Of Using Multi-temporal ASL And SWI To Improve The Diagnostic Accuracy Of Astrocytic Tumors

Objectives:Gliomas are the most common primary brain tumor.Different grades of gliomas have different treatments,and the precise classification of gliomas have important clinical significance.This study is based on the conventional MR examination,using mTI-ASL perfusion imaging,conventional sTI-ASL perfusion imaging,SWI imaging.Respectively,to observe perfusion information of glioma and intratumoral microhemorrhage state.Combined mTI-ASL and SWI sequences to assess glioma perfusion and microhemorrhage in order to improve preoperative diagnostic accuracyMaterials and methods:We collected 32 patients(19 men,13 women,median age,48 years).According to conventional MR examination diagnosed as gliomas,followed by mTI-ASL sequence,sTI-ASL sequence,and SWI sequence scan.Multiple ROIs were plotted in the solid portion of the CBF image of the ASL.Normalized nCBF-mTI and nCBF-sTI were obtained by averaging the CBF of the ROI in the tumor area/the CBF value of the normal semiovale center ROI.Normalized nCBF-mTI and nCBF-sTI were obtained from the mean CBF of the ROI of the tumor area/the CBF value of the normal semiovale center ROI,to observe the perfusion of high and low grade gliomas.SWI is the observation of the morphological and quantitative characteristics of the magnetic susceptibility signal within the tumor.Combined tumor perfusion information and microhemorrhage information to observe tumors.Results:In both high and low grade gliomas,there were statistical differences between nCBF-sTI and nCBF-mTI.The mean nCBF of high-grade glioma is higher than that of low-grade glioma.Significant differences in ITSS between high and low grade gliomas in SWI imaging.Low grade gliomas account for the largest proportion in grade I,and high-grade gliomas account for the largest proportion in grade III.The area under the ROC curve of nCBF-mTI,nCBF-sTI,and ITSS for grading gliomas has the highest nCBF-mTI,followed by nCBF-sTI,while ITSS is the smallest.The use of mTI-ASL combined with tumor perfusion information and SWI microhemorrhage information for the prediction of the rate of 87.5% for the two groups of gliomas.Conclusions:Independent use of sTI-ASL and mTI-ASL can be used as high and low grade tumor identification methods,and mTI-ASL has advantages over sTI-ASL.SWI can be independently used as a method for identifying high and low grade tumors.Combining mTI-ASL and SWI Sequences for better preoperative classification of gliomas.