Clinical Study Of Auxiliary Methods For Improving The Effect Of Intravenous Thrombolysis In Acute Ischemic Stroke

ObjectiveThis study attempted to assess the value of serum cystatin C level before thrombolysis,arterial intervention and intravascular ultrasound to explore its application in thrombolytic therapy of acute cerebral infarction.Methods1、Observation group using intravenous thrombolysis combined with interventional therapy,the control group to take a simple intravenous thrombolytic therapy.(TIMI),symptomatic intracranial hemorrhage rate and postoperative 3-month quality of life score(mRS)were compared between the two groups before and after treatment.2、 The T1 WI,T2WI and SWI sequences of 1.5T nuclear magnetic were used to scan.The content of serum cystatin C was detected by ELISA kit.The paraffin embedding method was used for pathological examination.3、Intravascular treatment under the guidance of intravascular ultrasound,the use of its plaque and lumen evaluation,through the virtual histological sequence analysis of plaque stability.4、 Using SPSS 20.0 statistical software for analysis,P <0.05 for the difference was statistically significant.Result1、The experimental group before and after treatment TIMI Ⅱ ~ Ⅲ grade blood flow 64.5% was significantly higher than the control group 37.3%.The incidence of symptomatic intracranial hemorrhage was 16.1% in the experimental group and 9.28% in the control group,6.5% in the mortality group and 3.9% in the control group,the difference was not statistically significant.Preoperative and postoperative 3-month quality of life score,the experimental group(61.3%)was superior to the control group(37.3%),the difference was statistically significant.2、 The experimental group of serum cystatin C content than the control group,the difference was statistically significant.Pathological examination showed that hemorrhagic lesions in the brain were consistent with the imaging features of SWI.3、 Intravascular ultrasound monitoring of plaque fiber cap stability,treatment of stenosis rate after treatment,occlusion of vascular recanalization,recovery of forward blood flow,cerebral perfusion imaging showed low perfusion status improved significantly.Conclusion1、 Intravenous thrombolysis combined with interventional therapy patients can better access TIMI Ⅱ ~ Ⅲ blood flow,improve the quality of life,but does not increase the incidence of postoperative intracranial hemorrhage and mortality.2、 Serum cystatin C levels in the brain after the micro-bleeding showed an increase in performance,and SWI test results and pathology consistent with the brain can be used as a micro-bleeding after the sensitive test indicators.3、 Intravascular ultrasound in the treatment of intravascular plays an important role in implantation directly more accurate,increased the success rate of recanalization surgery,reduce complications.