The Effect Of Tumor-derived Exosomes On Immune State Of The Host

Exosomes are a kind of vesicular structure secreted by living cells,which contain proteins,mi RNA,m RNA and other components derived from matermal cells.Exosomes are important media for intercellular material exchange and information transduction.Tumor-derived exosomes can affect the immune state of the host through multiple mechanisms,resulting in immune escape of the tumor.The present study focuses on the regulation of tumor-derived exosomes on a variety of immune cells,including effects on the killing activity of NK cells,promotion of macrophage polarization,inhibition of T cell proliferation,induction of immunosuppressive cell differentiation etc.We aim to deepen the understanding of the interaction between tumor and immunity and to explore novel immunotherapeutic targets.