The Influence Of ADD On Condylar Metabolism-A SPECT/CT Study

Objective: To evaluate the bone metabolism of condylar in patients with anterior disc displacement of temporomandibular joint by using SPECT/CT(single photon emission computed tomography/computed tomography)and investigate the objective law between the bone metabolism changes、courses and states.Methods:1.Case materials: During January 2016 to December 2016 in Bethune International Peace Hospital,130(31 male and 99 female;median age,interquartile range(25.00,31.30))patients complaining of clinical symptoms such as click sound,pain,limited mouth opening,definitely diagnosed as ADD by MRI were observed in this study,excluded trauma,tumor,heredity and other factors.All patients recorded the disc displacement time(start from snapping to the time of visit),and the degree of disc displacement was divided into I to V phases according to the Wilkes-Bronstein stage.2.Method: All patients underwent SPECT/CT on the TMJs before treatment,after then,we delimited the similar regions of interest(ROI)of both TMJs in the same plane,meanwhile,acquired time-radioactive nuclide curves and nuclide counts in 10 th min.At last,paired tests and correlated analysis were performed.Results: It was showed that the positive rate of condylar delayed phase accumulation was 86.92%.In 130 cases,the difference of counts of ROI in the healthy(21.865,13.460)and affected sides(26.256,15.480)was statistically significant(Z = 8.909,P = 0.000 < 0.05);there was a negative correlation between ROI counts and course of ADD(361.50,919.00)(P=0.000<0.05,correlation coefficient C=-0.332);in the young group,there was a correlation between ROI counts and course of ADD(360.00,918.75),disease stages(P=0.009,correlation coefficient C=-0.287;P=0.013,correlation coefficient C=-0.275).Conclusion:1.It was suggested that there was anomaly in the condylar metabolism of patients with ADD,manifested as delayed phase radionuclide delayed phase abnormal concentration of positive rate of 86.92%.2.The ROI counts of TMJ condyles were negatively correlated with the course,indicating that the condylar osteoblastic activity decreased with the time of disc displacement.