Relationship Between Lipoprotein A And In-stent Restenosis After PCI In Coronary Heart Disease

Objective:This article intends to use Logisitc regression analysis model to study the correlation between lipoprotein a levels and coronary heart disease post-PCI restenosis,in order to reduce the incidence of coronary heart disease PCI restenosis,to provide an effective,reliable and easy to check Biochemical Indicators.To improve clinicians' understanding of the relationship between lipoprotein a and restenosis after coronary PCI,and to provide a good basis for future research on the mechanism of restenosis after PCI.Method:1.Select 120 patients who had previous in-hospital and/or outpatient coronary angiography or coronary CT confirmed whether there was in-stent restenosis between December 2014 and June 2017.2.General Information: By asking history,general information about the patient,including age,gender,smoking history,etc.,is obtained and recorded in the questionnaire.3.Diagnostic criteria for diabetes are based on the "Guideline for the prevention and treatment of type 2 diabetes in China(2013 edition)".4.Standard criteria for stent restenosis after PCI: readings by 2 experienced interventional doctors,control group: intraluminal lumen stenosis <50%,no serious complications;restenosis group: intraluminal stenosis ?50%,Or the patient has chest tightness,chest pain and other symptoms.5.Biochemical indicators Triacylglycerols,high-density lipoproteins,low-density lipoproteins,total cholesterol: All results are provided in our biochemistry laboratory,normal reference values: triglycerides 0.6-1.7 mmol/L;total cholesterol 3.0-5.2 mmol/L;high-density lipoprotein 0.78-1.81 mmol/L;low-density lipoprotein 1.5-3.0 mmol/L6.Filter the data,then carry out logistic stepwise regression analysis of multi-factor and multi-category items,and build a model,and use the tree model to process the collinearity of variables.Results1.A total of 120 patients were included in this study and classified as ISR according to whether there was an ISR.Among them there were 74 males and 46 females,65 with diabetes history,55 with no diabetes,64 with smoking history,and 56 without smoking history.The measurement data were normal distribution after Kolmogorov-Smimov(K)test.P<0.05),both can be described by `x±s.2.Diabetes history,smoking history,age,apolipoprotein A,low-density lipoprotein,and high-density lipoprotein had significant differences in ISR(P<0.05).Gender and apolipoprotein A1 had no effect on ISR.Difference(P>0.05).3.With the increase of age,LDL,apolipoprotein A increase,the risk of ISR increases,the increase of high-density lipoprotein and the risk of ISR decrease.4.Exploring low-density lipoprotein and apolipoprotein A alone,even if triglycerides <1.62 mmol/L,CAP values> 299 dB/m,still have an effect on the number of lesions,it can be explained that the CAP value on the number of lesions The effect is independent of triglycerides.Conclusion1.This survey shows that diabetes history,smoking history,age,apolipoprotein A,low-density lipoprotein,and high-density lipoprotein all have an effect on ISR.Gender and apolipoprotein A1 have no effect on ISR.2.This study shows that the higher the Lp(a)value,the higher the probability of ISR occurrence.3.With increasing age,LDL,apolipoprotein A increase,IRS risk increases,high density lipoprotein increase,ISR risk decreases.4.This study shows that the effect of ISR on Lp(a)is independent of the presence of LDL.