Based On Diketopyrrolopyrrole Organic Semiconductor Material:Design,Synthesis And Biological Applications

In recent years,Photodynamic therapy(PDT),as a new therapies to treat the tumor and have significant function is starting to get more and more attention and research.Compared with the traditional methods of treating cancer,PDT has the characteristics of a low toxicity,trauma,and no resistance to the drug.Under the condition of light,the cancer cells will be killed by singlet oxygen,produced by photosensitizer molecule,to achieve the treatment of cancer,at the same time,control light can reduce the damage to normal cells.Yet,clinical treatment,PDT have many shortcomings,first of all,is the traditional photosensitizer material have complicated composition,strong hydrophobicity and poor biocompatibility,secondly,is due to the traditional photosensitizer most have a short wavelengths absorption,unable to kill deep cancer cells,moreover,the traditional photosensitizer material have low photovoltaic(pv)and poor light stability,unable to continuous treatment,so looking for a new material for PDT has gradually become the focus of photodynamic therapy research.Under such a background,based on the organic semiconductor material Diketopyrrolopyrrole,design materials with different molecular structure,and through the test to study the optical properties,electrochemical properties,and the effect of photodynamic,include the following contents:(1)The dissolution of the DPP is improved by alkylation and bromination,through Suzuki coupling,obtain the polymerization of the DPP and polycyclic aromatic hydrocarbons and the small molecule monomer formed by the DPP and polycyclic aromatic hydrocarbon coupling.Through the test,found that,due to the introduction of the construction of ? planar construction,enhance intermolecular ?-? stacking,increase ? conjugate electron,reduce molecular energy level,improve molecular photochemical activity.(2)Design and synthesis the small molecular material of the DPP's aniline structure,through the test,found that,due to the the presence of strong electron-withdrawing group dimethamidine,the molecules of DPP have a near-infrared absorption,contemporary,reduce molecular energy level improve molecular photochemical activity with a significant effect of photodynamic.(3)Design and synthesis the structure of the DPP with the hydroxy and bromine at the end,by contrast,the molecule of the bromine at the end of DPP have better light stability,effect of photodynamic,then,have a preliminary try at biology applications.