Observation The Clinical Effect Of Yangxin Decoction On Hypertensive Patients(Qi And Blood Two Deficiency) Complicated With Emotional Disorder By The Theory Of "Heart Lord God"

Objective Through the clinical randomized controlled study of Anshen Ding Zhi method combined with conventional antihypertensive drugs for 1 months in patients with hypertension(Qi and blood two deficiency)and anxiety,depression,and explore the efficacy and safety of Yangxin Anshen Ding Xuan decoction combined with conventional antihypertensive drugs to improve the treatment of the disease.Methods A total of 84 outpatients and hospitalized cases of primary hypertension with anxiety and depression were selected from the Department of Cardiology of the hospital of traditional Chinese medicine in Sichuan province from March 2017 to October 2017.TCM syndrome differentiation is Qi and blood two deficiency syndrome.Were randomly divided into experimental group(Yangxinanshen Dingxuan Decoction plus conventional antihypertensive drugs,42 cases)and control group(42 cases of conventional antihypertensive drugs and alprazolam in the treatment group),treatment for 1 months.Observe the two groups before and after treatment in patients with blood pressure rate and compliance rate,circadian rhythm of blood pressure and morning blood pressure peak changes,analysis of heart rate variability,anxiety and depression score changes,as well as before and after medication for first weeks,1 months of single symptom in TCM syndrome and TCM Syndrome scale changes and adverse reactions of(including the liver and kidney function,allergic reaction,etc.)were observed.Results1.Effectiveness assessments:This study included 84 cases,a total of 78 cases with complete clinical trials,The results showed: two groups of patients before treatment,systolic blood pressure,diastolic blood pressure,blood pressure variability,HAMA HAMD showed no significant difference(P >0.05);the two groups after treatment,systolic blood pressure and diastolic blood pressure were lower than before,the difference was statistically significant(P<0.05);2 weeks later,the test group of patients with systolic blood pressure and diastolic blood pressure compared with the control group,the difference was not statistically significant(P < 0.05);after 4 weeks,patients with systolic blood pressure in experimental group compared with the control group(P < 0.05),but there was no significant difference between the two groups of diastolic blood pressure;In either group of HAMA and HAMD score was lower than that before(P<0.05);In the last,the HAMA scores of the two sets was not statistically significant(P < 0.05);But,it's worth noting that the test group HAMD scores falling below the other side,the difference was statistically significance Meaning(P < 0.05);after four weeks later,the blood pressure variability of the patients in the test group was significantly different than that in the control group(P < 0.05);test group of patients with adverse reaction events is lower than that in the control group after treatment was statistically significant the difference(P < 0.05)According to the evaluation of TCM syndrome effect standard,the effective rate of intervention group was 86.32% and remain significantly higher than control group(P < 0.05).For irritability symptoms,the difference was not statistically significant(P=0.15>0.05);for spontaneous sweating,insomnia,palpitation,dizzy God fatigue,lusterless complexion and other symptoms,the difference was statistically significant(P<0.05).2.Safety assessments:In the test group and the routine control group,the general physical examination and the laboratory examination were not obvious before and after the treatment.There were no adverse reactions such as aggravation of target organ damage and allergic reaction in the experimental group,while the patients in the control group had somnolence,fatigue and other adverse reactions.The results showed that the drug used in the test group(Yangxin Anshen Dawei Decoction)had good safety.Conclusion Yangxin Anshen Dingxuan decoction combined with conventional antihypertensive drug efficiency and compliance rate,HAMA score and antihypertensive drugs alprazolam scheme comparison for hypertensive patients with anxiety and depression of patients with antihypertensive no difference;but Yangxinanshen Dingxuan decoction combined with conventional antihypertensive drugs for patients after 4 weeks for systolic blood pressure,HAMD score,main the symptoms,blood pressure variability and TCM symptoms were better than the pure western medicine group,and has statistical significance.At the same time,it has good clinical efficacy and safety.