Prognostic Value Of Interleukin-6 And Interleukin-8 In Laryngeal Squamous Cell Cancer

Objective:The aim of this study was to evaluate serum levels of interleukin-6(IL-6)and interleukin-8(IL-8)asprognostic variables in patients with laryngeal squamous cell cancer.Method:A total of 92 patients with primary diagnosis of laryngeal squamous cell cancer(LSCC),treated between2003 and 2005,were included in this evaluation.Preoperativeserum levels of IL-6 and IL-8 were measured byenzyme-linked immunosorbent assay methods.Results were compared according to clinical and pathological datecriteria.Result:Serum IL-6 and IL-8 levels were significantly higher in patients with LSCC compared to healthy controls(P\0.0001).Serum IL-6 level was associated with lymph node metastasis(P\0.001),T classification(P\0.001)and clinical stage(P = 0.001).Multivariate analysis indicated that serum IL-6 was an independent predictor of LSCC-specific progression-free survival(P = 0.049)and overall survival(P = 0.040).Higher serum IL-6 level(IL-6[9.7 pg/ml)was associated with a shortened overallsurvival and progression-free survival(P\0.05).Conclusion:Our data indicate that serum IL-6 is associated with the development and progression of LSCC.Serum IL-6 may serve as an independent prognostic marker for LSCC patients.