The Serum Levels Of Cardiac Troponin ? In The Prediction Of Early Neurogenic Pulmonary Edema After Subarachnoid Hemorrhage:a Meta-analysis

ObjectiveTo investigate the relationship between the serum levels of cardiac troponin I and early neurogenic pulmonary edema after subarachnoid hemorrhage.MethodsWe searched Pubmed,Embase and Cochrane library,and published domestic and foreign controlled studies about the relationship between the serum levels of cardiac troponin I and neurogenic pulmonary edema Since the data-base was built.Then,we excluded non-compliant documents,and statistically analyzed the results of included studies using Review Manager5.3 software.ResultsA total of 5 English studies were included in this study.There are related datas about comparing the relationship between the serum levels of cTn I and the occurrence of NPE in 4 studies;And two of including studies can compare gender differences in the occurrence of NPE.Heterogeneity test about the relationship between Increased cTnI expression in serum and the occurrence of NPE was I~2=0%,P=0.49,and the heterogeneity was no significant,studies were analyzed by using Mantel-Haenszel method of the fixed effect model.The combined effect of RR=2.10(95%CI:1.79~2.46),P<0.00001,the difference was statistically significant.Heterogeneity test about the relationship between gender and the occurrence of NPE was I~2=67%,P=0.08,there is some heterogeneity,studies were analyzed by using Mantel-Haenszel method of the random effect model.The combined effect of RR=1.16(95%CI:0.68~1.98),P=0.58,the difference was no statistically significant.ConclusionIncreased cTnI expression in serum is highly correlated with the occurrence of early NPE after subarachnoid hemorrhage;The early increase of cTnI levels in serum after SAH can be used as an auxiliary index to predict the occurrence of NPE after excluding cardiac diseases.