Advances In The Treatment Of Epstein-barr Virus-associated Tumors With EBV-CTLs

The Epstein-barr virus(EBV)is a member of the human herpesvirus gamma family and is the world's first recognized human tumorigenesis virus.Epstein-Barr virus infection is divided into lytic infections and latent infections,and latent infections are mainly related to tumorigenesis.The types of tumors associated with EB virus infection mainly include B cells,T cells,NK/T cells,epithelial cells,and smooth muscle cells,and different types of tumors determine the differences in the expression of latent virus antigens.Traditional treatment methods for tumors include surgery,chemotherapy,radiotherapy,or combination.Adoptive cellular immunotherapy is a new type of cancer treatment after traditional treatment.EBV-CTLs are a type of adoptive immunotherapy.This article reviews the related research progress of the molecular basis,different preparation methods and clinical applications of EBV-CTLs immunotherapy,and immune checkpoint inhibitors to enhance the anti-tumor effect of EBV-CTLs,in order to improve the efficiency of the treatment of patients with EBV infection-associated tumors and improve the quality of the patient's life.